ArticleWorld journal of gastrointestinal surgery2010
Non-invasive assessment of barrier integrity and function of the human gut.
Article in World journal of gastrointestinal surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02734238 (Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial
Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability.PloS one · 2022Pooled it
- Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis.International journal of molecular sciences · 2021Trial
- Trial
- Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.The Journal of surgical research · 2019Trial
- A retrospective analysis of risk factors for intestinal necrosis in pediatric secondary intussusception.BMC pediatrics · 2026Article
- Intestinal permeability and the zonulin pathway: tight junctions, mucosal immunity, dietary modulators and clinical relevance.Frontiers in nutrition · 2026Review
- Tight junction proteins and intestinal health in preterm infants.Journal of neonatal-perinatal medicine · 2025Review
- Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane.Current protein & peptide science · 2025Review
- Biomarkers Unveiling the Interplay of Mind, Nervous System, and Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Gut microbiota changes in healthy individuals, obstructive sleep apnea patients, and patients treated using continuous positive airway pressure: a whole-genome metagenomic analysis.Sleep & breathing = Schlaf & Atmung · 2024Article
- Role of Claudin- 3 as a biomarker of gut-skin axis integrity in patients with psoriasis.Archives of dermatological research · 2024Article
- Does Ileus Represent the Forgotten End Organ Failure in Critical Illness?Current gastroenterology reports · 2024Review
- Associations between various markers of intestinal barrier and immune function after a high-intensity exercise challenge.Physiological reports · 2024Article
- ASO Author Reflections: Loss of Intestinal Integrity During Oncological Surgery and Postoperative Complications: A Complex Relationship.Annals of surgical oncology · 2024Article
- Gender-affirming hormone therapy preserves skeletal maturation in young mice via the gut microbiome.The Journal of clinical investigation · 2024Article
- Association of Blast Exposure in Military Breaching with Intestinal Permeability Blood Biomarkers Associated with Leaky Gut.International journal of molecular sciences · 2024Article
- The effects of dairy on the gut microbiome and symptoms in gastrointestinal disease cohorts: a systematic review.Gut microbiome (Cambridge, England) · 2024Review
- Role of Stress on Driving the Intestinal Paracellular Permeability.Current issues in molecular biology · 2023Review
- Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?Neurobiology of stress · 2023Review
- Alcohol-associated bowel disease: new insights into pathogenesis.eGastroenterology · 2023Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease, and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion, including trauma and major surgery. Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease. A variety of tests have been developed to assess intestinal epithelial cell damage, intestinal tight junction status and consequences of intestinal barrier integrity loss, i.e. increased intestinal permeability. This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.