ArticleWorld journal of gastrointestinal endoscopy2010
Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management.
Article in World journal of gastrointestinal endoscopy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- A Systematic Review of Technical Parameters for MR of the Small Bowel in non-IBD Conditions over the Last Ten Years.Scientific reports · 2019Pooled it
- Surgical treatment of neuroendocrine tumors in the second portion of the duodenum: a single center experience and systematic review of the literature.Langenbeck's archives of surgery · 2017Pooled it
- Controversies in NEN: An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms.Journal of neuroendocrinology · 2025Review
- Treatment outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumors.Journal of gastrointestinal oncology · 2024Article
- Risk factors for lymph node metastasis and indication of local resection in duodenal neuroendocrine tumors.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options.Molecular and clinical oncology · 2019Article
- Clinicopathological characteristics and frequency of multiple rectal neuroendocrine tumors: a single-center retrospective study.International journal of colorectal disease · 2019Article
- The multidisciplinary team for gastroenteropancreatic neuroendocrine tumours: the radiologist's challenge.Radiology and oncology · 2019Review
- Risk factors for lymph node metastasis in duodenal neuroendocrine tumors: A retrospective, single-center study.Medicine · 2019Observational
- Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line.Oncotarget · 2019Article
- Neuroendocrine Carcinoma of Duodenum-an Uncommon Tumour at an Unusual Site.Indian journal of surgical oncology · 2019Article
- Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma.Oncotarget · 2018Article
- Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors.International journal of endocrinology · 2018Review
- Early Gastroenteropancreatic Neuroendocrine Tumors: Endoscopic Therapy and Surveillance.Visceral medicine · 2017Review
- The slow progressive nature of duodenal neuroendocrine tumor: a case report of long-term observation over 14 years.Clinical journal of gastroenterology · 2017Article
- Early diagnosis and treatment of gastrointestinal neuroendocrine tumors.Oncology letters · 2016Article
- Management of gastric and duodenal neuroendocrine tumors.World journal of gastroenterology · 2016Review
- A Multi-institutional Analysis of Duodenal Neuroendocrine Tumors: Tumor Biology Rather than Extent of Resection Dictates Prognosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Syndromic versus non-syndromic sporadic gastrin-producing neuroendocrine tumors of the duodenum: comparison of pathological features and biological behavior.Virchows Archiv : an international journal of pathology · 2016Article
- Surgical Treatment of NEN of Small Bowel: A Retrospective Analysis.World journal of surgery · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today, most neuroendocrine tumors (NETs) of the duodenum are detected "incidentally" and therefore recognized at an early stage. Duodenal NETs which are well differentiated, not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm, for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with long-acting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management, tumor biology, type, localization and stage of the neoplasm, as well as the patient's individual circumstances have to be taken into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.