ArticleAIDS (London, England)2011
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
Article in AIDS (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.Journal of genetics · 2018Pooled it
- Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.PLoS pathogens · 2013Pooled it
- Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition.The Journal of infectious diseases · 2012Pooled it
- Transethnic meta-analysis of genomewide association studies.Genetic epidemiology · 2011Pooled it
- Trial
- Host Genetic Regulation of NLRP3 Inflammasome Cytokines Reveals Immune and Vascular Pathways in HIV.medRxiv : the preprint server for health sciences · 2026Article
- HIV-1 and human genetic variation.Nature reviews. Genetics · 2021Review
- The Emerging Role for CTL Epitope Specificity in HIV Cure Efforts.The Journal of infectious diseases · 2021Review
- Minding the gap in HIV host genetics: opportunities and challenges.Human genetics · 2020Review
- Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2).Genes and immunity · 2019Article
- Population Structure and Implications on the Genetic Architecture of HIV-1 Phenotypes Within Southern Africa.Frontiers in genetics · 2019Review
- Large-Scale "OMICS" Studies to Explore the Physiopatholgy of HIV-1 Infection.Frontiers in genetics · 2019Review
- The critical needs and challenges for genetic architecture studies in Africa.Current opinion in genetics & development · 2018Review
- Interaction of the Host and Viral Genome and Their Influence on HIV Disease.Frontiers in genetics · 2018Review
- Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.PloS one · 2018Article
- Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.PLoS pathogens · 2017Article
- Diversity and inclusion in genomic research: why the uneven progress?Journal of community genetics · 2017Article
- Molecular epidemiology of infectious diseases.Electronic physician · 2017Review
- Host genetic variation and HIV disease: from mapping to mechanism.Immunogenetics · 2017Review
- Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression.Journal of acquired immune deficiency syndromes (1999) · 2016Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveTo date, CCR5 variants remain the only human genetic factors to be confirmed to impact HIV-1 acquisition. However, protective CCR5 variants are largely absent in African populations, in which sporadic resistance to HIV-1 infection is still unexplained. We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans.
methodsWe performed a genome-wide association study (GWAS) in a population of 1532 individuals from Malawi, a country with high prevalence of HIV-1 infection. Using single-nucleotide polymorphisms (SNPs) present on the genome-wide chip, we also investigated previously reported associations with HIV-1 susceptibility or acquisition. Recruitment was coordinated by the Center for HIV/AIDS Vaccine Immunology at two sexually transmitted infection clinics. HIV status was determined by HIV rapid tests and nucleic acid testing.
resultsAfter quality control, the population consisted of 848 high-risk seronegative and 531 HIV-1 seropositive individuals. Logistic regression testing in an additive genetic model was performed for SNPs that passed quality control. No single SNP yielded a significant P value after correction for multiple testing. The study was sufficiently powered to detect markers with genotype relative risk 2.0 or more and minor allele frequencies 12% or more.
conclusionThis is the first GWAS of host determinants of HIV-1 susceptibility, performed in an African population. The absence of any significant association can have many possible explanations: rarer genetic variants or common variants with weaker effect could be responsible for the resistance phenotype; alternatively, resistance to HIV-1 infection might be due to nongenetic parameters or to complex interactions between genes, immunity and environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.