ArticleScience translational medicine2010
Personalized prostate cancer screening: improving PSA tests with genomic information.
Article in Science translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Benefits and Harms of Screening for Prostate Cancer in Adults Aged 18 Years and Older: A Systematic Review.Current oncology (Toronto, Ont.) · 2026Pooled it
- Multigene panels in prostate cancer risk assessment: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Pooled it
- Historical prostate cancer screening and treatment outcomes from a single institution.Clinical medicine & research · 2012Trial
- Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men.Prostate cancer and prostatic diseases · 2021Article
- Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis.Cancer prevention research (Philadelphia, Pa.) · 2021Article
- Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.Prostate cancer and prostatic diseases · 2021Article
- Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.Nature communications · 2021Article
- A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.BMJ (Clinical research ed.) · 2018Article
- Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.Nature communications · 2017Article
- Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy.PloS one · 2015Article
- National Cancer Institute Prostate Cancer Genetics Workshop.Cancer research · 2011Article
- Diverse functional networks of Tbx3 in development and disease.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
The use of a prostate-specific antigen (PSA) test to screen for prostate cancer is controversial because of its modest predictive value and the potential overdiagnosis and over-treatment of the disease. A research article in this issue of Science Translational Medicine describes single-nucleotide polymorphisms (SNPs) in or near six genes that are independently associated with serum PSA concentrations and that help to explain interindividual PSA variation. Three of these SNPs are also associated with prostate biopsy outcomes. These findings are an important step toward incorporating genetic markers into PSA screening, with the ultimate goal of devising personalized PSA tests for use in the clinic.
Indexed as
Identifiers
21160075What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.