Evidence map›Paper›PMID 21160056›Full record

ArticleCirculation2011

Heart disease and stroke statistics--2011 update: a report from the American Heart Association.

Véronique L Roger, Alan S Go, Donald M Lloyd-Jones, Robert J Adams, Jarett D Berry, Todd M Brown, Mercedes R Carnethon, Shifan Dai, Giovanni de Simone, Earl S Ford and 32 more

Erratum issued 14 registry-linked trialsAbstract read
In one paragraph

Article in Circulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 14 registered trials, which are not on this map. Cited by 2,088 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,088citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01665521 nacompletednot on this mapstarted 2012, after this paper: background citation

Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain

TypeinterventionalSponsorWake Forest University Health SciencesRan2012 to 2018Enrolled282ConditionsAcute Coronary Syndrome, Chest PainArmsHEART Pathway
NCT01688856 nacompletednot on this mapstarted 2013, after this paper: background citation

Optimizing Contralaterally Controlled FES for Acute Upper Limb Hemiplegia

TypeinterventionalSponsorMetroHealth Medical CenterRan2013 to 2018Enrolled67ConditionsStroke, Hemiparesis, HemiplegiaArmsElectrical Stimulator
NCT01821131 naunknown statusnot on this mapstarted 2014, after this paper: background citation

A Dose Response, Randomized, Controlled, Double-blind, Cross-over Trial to Determine the LDL Cholesterol Lowering Effect of Ground Flaxseed in Adults With Above Optimal Plasma LDL Concentrations

TypeinterventionalSponsorSt. Boniface HospitalRan2014 to 2025Enrolled76ConditionsAbove Optimal Plasma LDL ConcentrationsArmsmuffin
NCT02056964 completednot on this mapstarted 2013, after this paper: background citation

The HEART Pathway: Bridging the Gap Between Operations, Research, and Education

TypeobservationalSponsorWake Forest University Health SciencesRan2013 to 2019Enrolled14,717ConditionsChest Pain, Acute Coronary Syndrome, Chest Pain Atypical Syndrome, Chest Pain Rule Out Myocardial Infarction
NCT02709135 completednot on this mapstarted 2016, after this paper: background citation

Can Pre-Hospital Use of the HEART Score and Abbott i-STAT® Point-of-Care Troponin Predict Major Adverse Cardiovascular Events: the PARA-HEART Pilot Implementation

TypeobservationalSponsorWake Forest University Health SciencesRan2016 to 2018Enrolled511ConditionsAcute Coronary Syndrome, Chest Pain
NCT02726685 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effects of Respiratory Training on Respiratory and Functional Performance in Patients With Stroke

TypeinterventionalSponsorChung Shan Medical UniversityRan2018 to 2019Enrolled70ConditionsStrokeArmsrespiratory training., sham training.
NCT03084510 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

REPRISE China: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Edge™ Valve System - Clinical Evaluation in China

TypeinterventionalSponsorBoston Scientific CorporationRan2020 to 2020Enrolled0ConditionsStenoses, Aortic ValveArmsLotus Edge™ Valve System
NCT03093948 naterminatednot on this mapstarted 2017, after this paper: background citation

Effect of Remote Ischemic Post-conditioning on Neurologic and Cardiac Recovery in Out-of-hospital Cardiac Arrest

TypeinterventionalSponsorChonnam National University HospitalRan2017 to 2019Enrolled58ConditionsOut-Of-Hospital Cardiac ArrestArmsRemote ischemic post-conditioning
NCT03236545 nacompletednot on this mapstarted 2016, after this paper: background citation

Mechanisms of Vascular Dysfunction in Women: Role of Estradiol

TypeinterventionalSponsorUniversity of DelawareRan2016 to 2022Enrolled48ConditionsCardiovascular Risk FactorArmsNo to Low Endogenous Estrogen, Estradiol
NCT03452709 nacompletednot on this map

Clinical Trial of the Effectiveness of Non-pharmacological Interventions (Physical Activity + ABPM) in Patients With Cardiovascular Risk Factors in Primary Care

TypeinterventionalSponsorFundacion para la Formacion e Investigacion Sanitarias de la Region de MurciaRan2011 to 2016Enrolled3,656ConditionsCardiovascular DiseaseArmstherapeutic exercise, ABPM ambulatory blood pressure monitoring
NCT03621202 nacompletednot on this mapstarted 2018, after this paper: background citation

A Clinical Study to Evaluate the Safety and Accuracy of the Saranas Early Bird Bleed Monitoring System for the Detection of Endovascular Procedure Related Bleeding Events

TypeinterventionalSponsorSaranas, Inc.Ran2018 to 2019Enrolled66ConditionsEndovascular ProceduresArmsSaranas Early Bird Bleed Monitoring System (EBBMS)
NCT04467879 naterminatednot on this mapstarted 2020, after this paper: background citation

A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients

TypeinterventionalSponsorZona Health, IncRan2020 to 2022Enrolled146ConditionsHypertension, SystolicArmsZona Plus Device, Control Device
NCT05371145 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Carnosine for Peripheral Arterial Disease Patients (Car-PAD)

TypeinterventionalSponsorShahid BabaRan2023 to 2024Enrolled20ConditionsPeripheral Arterial DiseaseArmsCarnosine
NCT06480760 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Carnosine In Patients With Peripheral Arterial Disease Patients; Randomized Intervention Trial (CIPHER)

TypeinterventionalSponsorShahid BabaRan2025 to 2028Enrolled144ConditionsPeripheral Arterial DiseaseArmsCarnosine
3 · Its place in the literature

Who cites it

2,088 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Safety and effectiveness of Co-careldopa for motor recovery in post-stroke patients: A Systematic Review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pravastatin for lowering lipids.The Cochrane database of systematic reviews · 2023 · on this map
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cardiovascular Benefits of Menopause Hormone Treatment is Age-Dependent.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Review

2,028 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
  • Erratum issued
5 · Who and what money

Authors and funding

42 authors.

Véronique L Roger
Alan S Go
Donald M Lloyd-Jones
Robert J Adams
Jarett D Berry
Todd M Brown
Mercedes R Carnethon
Shifan Dai
Giovanni de Simone
Earl S Ford
Caroline S Fox
Heather J Fullerton
Cathleen Gillespie
Kurt J Greenlund
Susan M Hailpern
John A Heit
P Michael Ho
Virginia J Howard
Brett M Kissela
Steven J Kittner
Daniel T Lackland
Judith H Lichtman
Lynda D Lisabeth
Diane M Makuc
Gregory M Marcus
Ariane Marelli
David B Matchar
Mary M McDermott
James B Meigs
Claudia S Moy
Dariush Mozaffarian
Michael E Mussolino
Graham Nichol
Nina P Paynter
Wayne D Rosamond
Paul D Sorlie
Randall S Stafford
Tanya N Turan
Melanie B Turner
Nathan D Wong
Judith Wylie-Rosett
American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Funding

The NINDS International Stroke Genetics Consortium StudyU01NS069208 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2010 to 2013
$9.4M
Framingham Heart Study/FoxZIAHL006094 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FOX, CAROLINE · 2010 to 2015
$6.9M
Outcome and Quality of Life after Diabetic StrokeK23NS045054 · NINDS · UNIVERSITY OF CINCINNATI · PI KISSELA, BRETT M · 2003 to 2007
$761k
Magnetic Resonance Imaging of Carotid Artery Subclincal AtherosclerosisK23HL092229 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BERRY, JARETT D · 2009 to 2013
$661k
NHLBI NIH HHS K23 HL092229NINDS NIH HHS K23 NS045054NINDS NIH HHS U01 NS069208
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

American Heart AssociationAdultAgedAged, 80 and overDiabetes ComplicationsFemaleHeart DiseasesHumansHypercholesterolemiaHypertensionIncidenceKidney Failure, ChronicMaleMetabolic SyndromeMiddle AgedMotor Activity

Identifiers

PMID21160056
PMCPMC4418670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 8 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.