ArticleProceedings of the National Academy of Sciences of the United States of America1990
Complete sequence of human vinculin and assignment of the gene to chromosome 10.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
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- Genes responsible for proliferation, differentiation, and junction adhesion are significantly up-regulated in human ovarian granulosa cells during a long-term primary in vitro culture.Histochemistry and cell biology · 2019Article
- Review
- Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.Molecular & cellular proteomics : MCP · 2010Article
- Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy.Molecular and cellular biology · 2007Article
- Decomposition of protein tryptophan fluorescence spectra into log-normal components. II. The statistical proof of discreteness of tryptophan classes in proteins.Biophysical journal · 2001Article
- Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector.Journal of virology · 1999Article
- Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.The Journal of cell biology · 1997Article
- A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.The EMBO journal · 1997Article
- Gene mapping of familial autosomal dominant dilated cardiomyopathy to chromosome 10q21-23.The Journal of clinical investigation · 1996Article
- Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects.The Journal of experimental medicine · 1996Article
- Isolation of InsP4 and InsP6 binding proteins from human platelets: InsP4 promotes Ca2+ efflux from inside-out plasma membrane vesicles containing 104 kDa GAP1IP4BP protein.The Biochemical journal · 1996Article
- Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites.The Biochemical journal · 1996Article
- High-resolution genetic mapping of the gunmetal gene which regulates platelet production.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Vinculin, talin and focal adhesions.Journal of muscle research and cell motility · 1996Review
- Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Interaction of the 47-kDa talin fragment and the 32-kDa vinculin fragment with acidic phospholipids: a computer analysis.Biophysical journal · 1995Article
- The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectively.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin.The Journal of cell biology · 1994Article
- Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the complete sequence of human vinculin, a cytoskeletal protein associated with cell-cell and cell-matrix junctions. Comparison of human and chicken embryo vinculin sequences shows that both proteins contain 1066 amino acids and exhibit a high level of sequence identity (greater than 95%). The region of greatest divergence falls within three 112-amino acid repeats spanning residues 259-589. Interestingly, nematode vinculin lacks one of these central repeats. The regions of human vinculin that are N- and C-terminal to the repeats show 54% and 61% sequence identity, respectively, to nematode vinculin. Southern blots of human genomic DNA hybridized with short vinculin cDNA fragments indicate that there is a single vinculin gene. By using a panel of human-rodent somatic cell hybrids, the human vinculin gene was mapped to chromosome 10q11.2-qter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.