ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia.The Journal of physiology · 2012Trial
- Intermittent phrenic afferent activation induces phrenic motor plasticity.Journal of neurophysiology · 2026Article
- Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.Physiological reports · 2025Article
- Classification of directionally specific vagus nerve activity using an upper airway obstruction model in anesthetized rodents.Scientific reports · 2021Article
- Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity.Journal of neuroinflammation · 2021Article
- Neural memory of the genioglossus muscle during sleep is stage-dependent in healthy subjects and obstructive sleep apnoea patients.The Journal of physiology · 2018Article
- Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.Scientific reports · 2018Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Article
- Noradrenergic Activation of Hypoglossal Nucleus Modulates the Central Regulation of Genioglossus in Chronic Intermittent Hypoxic Rats.Frontiers in neurology · 2017Article
- Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis.Comprehensive Physiology · 2016Review
- Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Learning to breathe: habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.Respiratory physiology & neurobiology · 2014Article
- Article
- Spinal TNF is necessary for inactivity-induced phrenic motor facilitation.The Journal of physiology · 2013Article
- Inactivity-induced respiratory plasticity: protecting the drive to breathe in disorders that reduce respiratory neural activity.Respiratory physiology & neurobiology · 2013Review
- Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Computational models and emergent properties of respiratory neural networks.Comprehensive Physiology · 2012Review
- Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The respiratory control system is not just reflexive, it is smart, it learns, and, in fact, it has a memory. The respiratory system listens to and carefully remembers how previous stimuli affect breathing. Respiratory memory is laid down by adjusting synaptic strength between respiratory neurons. For example, repeated hypoxic bouts trigger a form of respiratory memory that functions to strengthen the ability of respiratory motoneurons to trigger contraction of breathing muscles. This type of respiratory plasticity is known as long-term facilitation (LTF). Although chemical feedback, such as hypoxia, initiates LTF, it is unknown whether natural modulation of mechanical feedback (from vagal inputs) also causes motor plasticity. Here, we used reverse microdialysis, electrophysiology, neuropharmacology, and histology to determine whether episodic modulation of vagally mediated mechanical feedback is able to induce respiratory LTF in anesthetized adult rats. We show that repeated obstructive apneas disrupt vagal feedback and trigger LTF of hypoglossal motoneuron activity and genioglossus muscle tone. This same stimulus does not cause LTF of diaphragm activity. Hypoxic episodes do not cause apnea-induced LTF; instead, LTF is triggered by modulation of vagal feedback. Unlike hypoxia-induced respiratory plasticity, vagus-induced LTF does not require 5-HT(2) receptors but instead relies on activation of α1-adrenergic receptors on hypoglossal motoneurons. In summary, we identify a novel form of hypoxia- and 5-HT-independent respiratory motor plasticity that is triggered by physiological modulation of vagal feedback and is mediated by α1-adrenergic receptor activation on (or near) hypoglossal motoneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.