ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- The role of genes related to excitotoxicity in glioma prognosis.Discover oncology · 2025Article
- Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates.International journal of molecular sciences · 2023Review
- S-Nitrosylation in Tumor Microenvironment.International journal of molecular sciences · 2021Review
- Dynamic regulation of the cholinergic system in the spinal central nervous system.Scientific reports · 2020Article
- Article
- Large-Scale Analysis of the Diversity and Complexity of the Adult Spinal Cord Neurotransmitter Typology.iScience · 2019Article
- S-Nitrosylation: An Emerging Paradigm of Redox Signaling.Antioxidants (Basel, Switzerland) · 2019Review
- The role of neuronal nitric oxide and its pathways in the protection and recovery from neurotoxin-inducedAIMS neuroscience · 2019Article
- Complementary expression of calcium binding proteins delineates the functional organization of the locomotor network.Brain structure & function · 2018Article
- The Relationship between Estrogen and Nitric Oxide in the Prevention of Cardiac and Vascular Anomalies in the Developing Zebrafish (Danio Rerio).Brain sciences · 2016Article
- Article
- Characterisation and comparison of temporal release profiles of nitric oxide generating donors.Journal of neuroscience methods · 2015Article
- The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling.Cell reports · 2014Article
- Article
- Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Electrical activity as a developmental regulator in the formation of spinal cord circuits.Current opinion in neurobiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nitric oxide (NO) is a signaling molecule that is synthesized in a range of tissues by the NO synthases (NOSs). In the immature nervous system, the neuronal isoform of NOS (NOS1) is often expressed during periods of axon outgrowth and elaboration. However, there is little direct molecular evidence to suggest that NOS1 influences these processes. Here we address the functional role of NOS1 during in vivo zebrafish locomotor circuit development. We show that NOS1 is expressed in a population of interneurons that lie close to nascent motoneurons of the spinal cord. To determine how this protein regulates spinal network assembly, we perturbed NOS1 expression in vivo with antisense morpholino oligonucleotides. This treatment dramatically increased the number of axon collaterals formed by motoneuron axons, an effect mimicked by pharmacological inhibition of the NO/cGMP signaling pathway. In contrast, exogenous elevation of NO/cGMP levels suppressed motor axon branching. These effects were not accompanied by a change in motoneuron number, suggesting that NOS1 does not regulate motoneuron differentiation. Finally we show that perturbation of NO signaling affects the ontogeny of locomotor performance. Our findings provide evidence that NOS1 is a key regulator of motor axon ontogeny in the developing vertebrate spinal cord.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.