ArticleJournal of clinical microbiology2011
Using molecular epidemiology to trace transmission of nosocomial norovirus infection.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Using molecular methods to delineate norovirus outbreaks: a systematic review.Archives of virology · 2024Pooled it
- Unraveling the Transmission Dynamics of a Novel Norovirus GII.17[P17] Lineage During Two Consecutive Outbreaks in a Spanish Hospital.Journal of medical virology · 2026Article
- Risk factors for norovirus infection in healthcare workers during nosocomial outbreaks: a cross-sectional study.Antimicrobial resistance and infection control · 2021Article
- Norovirus outbreak in a natural playground: A One Health approach.Zoonoses and public health · 2020Article
- Using hospital administrative data to infer patient-patient contact via the consistent co-presence algorithm.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2019Article
- Norovirus Transmission Dynamics in a Pediatric Hospital Using Full Genome Sequences.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Selected Viruses Detected on and in our Food.Current clinical microbiology reports · 2018Review
- Detection of Norovirus GII.17 Kawasaki 2014 in Shellfish, Marine Water and Underwater Sewage Discharges in Italy.Food and environmental virology · 2017Article
- Norovirus GII.Pe Genotype: Tracking a Foodborne Outbreak on a Cruise Ship Through Molecular Epidemiology, Brazil, 2014.Food and environmental virology · 2017Article
- A universal primer-independent next-generation sequencing approach for investigations of norovirus outbreaks and novel variants.Scientific reports · 2017Article
- High prevalence of GII norovirus in hospitalized children with acute diarrhea, in Beijing.PloS one · 2017Article
- Next-generation sequencing and norovirus.Future virology · 2016Article
- The Where is Norovirus Control Lost (WINCL) Study: an enhanced surveillance project to identify norovirus index cases in care settings in the UK and Ireland.Journal of infection prevention · 2016Article
- Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014.Nature communications · 2015Article
- Outbreak column 18: The undervalued work of outbreak: prevention, preparedness, detection and management.Journal of infection prevention · 2015Article
- Separate norovirus outbreaks linked to one source of imported frozen raspberries by molecular analysis, Denmark, 2010-2011.Epidemiology and infection · 2015Article
- Emergence of a novel GII.17 norovirus – End of the GII.4 era?Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2015Article
- Shedding of norovirus in symptomatic and asymptomatic infections.Epidemiology and infection · 2015Article
- Norovirus genotype profiles associated with foodborne transmission, 1999-2012.Emerging infectious diseases · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nosocomial norovirus (NoV) infection is common and may lead to complications in vulnerable hospitalized patients. Understanding sources and modes of transmission of noroviruses within health care settings will support the design of evidence-based strategies for reducing introduction and further spread. We sequenced a highly variable segment of the genome to identify possible clusters in patients with and without acute gastroenteritis who were hospitalized in the period 2002-2007. Admission and sampling dates were used to separate patients with nosocomial infection from those without nosocomial infection. Epidemiological clustering retrieved 22 clusters, defined as ≥ 2 patients with nosocomial infection on the same ward within 5 days. In total, 264 patients (of 2,458 tested) were diagnosed with NoV infection, and 61% of the patient strains could be genotyped. Of those, 51% (n = 82) belonged to GII.4, 34% (n = 54) belonged to GII.3, and 15% (n = 24) belonged to other genotypes (GI.6B, GII.17, GII.7, and GII.2). In children's wards, GII.3 strains were associated with nosocomial spread more often than other viruses were, whereas in adults this was the case for GII.4 strains. Sequence alignment recognized 11 new clusters based on identical P2 domains (4 GII.3 and 7 GII.4 clusters), involving patients in different wards. This increased the total number of recognized clusters by 50%. Five of these clusters involved at least one outpatient, providing a possible target for improvement of infection control. We concluded that the use of sequence-based typing should be considered for identifying hidden nosocomial clusters of NoV infections within health care settings.
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Registered trials
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