Evidence map›Paper›PMID 21159882›Full record

ArticleJournal of virology2011

Antiviral activity of human immunodeficiency virus type 1 Gag-specific cytotoxic T lymphocyte targeting is not necessarily intrinsically superior to envelope targeting.

Diana Y Chen, Arumugam Balamurugan, Hwee L Ng, Otto O Yang

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. HLA-B*14:02-Restricted Env-Specific CD8Journal of virology · 2017
    Trial
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Diana Y ChenDepartment of Microbiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Arumugam Balamurugan
Hwee L Ng
Otto O Yang
University of California, Los Angeles · USBlack AIDS Institute · US

Funding

HIV-1 Excape from Inhibiton by Cytotoxic T LymphocytesR01AI043203 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, OTTO O · 1998 to 2012
$4.6M
Immune Pressure on HIV-1 Nef by Cytotoxic T LymphocytesR01AI051970 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, OTTO O · 2002 to 2011
$4.1M
NIAID NIH HHS AI043203NIAID NIH HHS AI051970NIAID NIH HHS R01 AI043203NIAID NIH HHS R01 AI051970
6 · The paper itself

Abstract

Across several cohorts, human immunodeficiency virus type 1 (HIV-1) Gag- and Env-specific CD8(+) T lymphocyte (CTL) responses have demonstrated inverse and positive correlations, respectively, to viremia. The mechanism has been proposed to be superior antiviral activity of Gag-specific CTLs in general. Addressing this hypothesis, we created two HIV-1 constructs with an epitope translocated from Gag (SLYNTVATL, SL9) to Env, thereby switching the protein source of the epitope. A virus expressing SL9 in Env was similar to the original virus in susceptibility to SL9-specific CTLS. This finding suggests that Env targeting is not intrinsically inferior to Gag targeting for CTL antiviral activity.

Indexed as

Cell Lineenv Gene Products, Human Immunodeficiency Virusgag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHumansT-Lymphocytes, Cytotoxicenv Gene Products, Human Immunodeficiency Virusgag Gene Products, Human Immunodeficiency Virus

Identifiers

PMID21159882
PMCPMC3067792
OpenAlexW2111100844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.