SynthesisThe Journal of clinical endocrinology and metabolism2011
Relationship between vitamin D, parathyroid hormone, and bone health.
Synthesis in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does vitamin D deficiency affect functional outcomes in hip fracture patients? A meta-analysis of cohort studies.Journal of endocrinological investigation · 2024Pooled it
- Pooled it
- The Dose-Response Effects of Vitamin DNutrients · 2026Trial
- Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males.European journal of applied physiology · 2014Trial
- Postoperative PTH measurement is not a reliable predictor for hypocalcemia after total thyroidectomy in vitamin D deficiency: prospective study of 203 cases.World journal of surgery · 2014Trial
- Trial
- Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial.The American journal of clinical nutrition · 2013Trial
- Effects of vitamin D supplementation in older African American women.The Journal of clinical endocrinology and metabolism · 2013Trial
- Can one or two high doses of oral vitamin D3 correct insufficiency in a non-supplemented rheumatologic population?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Trial
- Is a daily supplementation with 40 microgram vitamin D3 sufficient? A randomised controlled trial.European journal of nutrition · 2012Trial
- The effect of vitamin D on calcium absorption in older women.The Journal of clinical endocrinology and metabolism · 2012Trial
- Article
- Vitamin D Status in Polish Military Personnel: Associations with Supplementation, Seasonality, and the GC rs2282679 Polymorphism.Nutrients · 2026Article
- Letter to "Postoperative Complications of Single-Level Lumbar Spine Fusion in Patients With Preoperative Vitamin D Deficiency: A Retrospective Cohort Study".Global spine journal · 2026Article
- Review
- Association of the vitamin D metabolite ratio with bone turnover markers and changes in volumetric BMD.JBMR plus · 2026Article
- The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review.Annals of medicine · 2025Review
- Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood.The Journal of nutrition · 2025Observational
- Evaluation of the age-specific relationship between PTH and vitamin D metabolites.Bone reports · 2024Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
contextThere is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.
objectiveThe objective of the study was to examine the evidence for a threshold value of serum 25-hydroxyvitamin D (25OHD) that defines vitamin D insufficiency as it relates to bone health. DESIGN AND
participantsThis was a cross-sectional analysis of baseline data in 488 elderly Caucasian women, mean age 71 yr, combined with a literature review of 70 studies on the relationship of serum PTH to serum 25OHD.
settingThe study was conducted in independent-living women in the midwest United States.
main outcome measureThe relationship between serum 25OHD, serum PTH, and serum osteocalcin and 24-h urine N-telopeptides was evaluated.
resultsSerum PTH was inversely correlated with serum 25OHD (r = -0.256, P < 0.0005), but no threshold as defined by suppression of serum PTH was found within the serum 25OHD range 6-60 ng/ml (15-150 nmol/liter). However, in contrast, there was a threshold for bone markers, serum osteocalcin and urine N-telopeptides, that increased only below a serum 25OHD of approximately 18 ng/ml (45 nmol/liter). Calcium absorption was not correlated with serum PTH and serum 25OHD, and no threshold was found. A literature review of 70 studies generally showed a threshold for serum PTH with increasing serum 25OHD, but there was no consistency in the threshold level of serum 25OHD that varied from 10 to 50 ng/ml (25-125 nmol/liter).
conclusionsVitamin D insufficiency should be defined as serum 25OHD less than 20 ng/ml (50 nmol/liter) as it relates to bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.