Evidence map›Paper›PMID 21159791›Full record

SynthesisThe American journal of clinical nutrition2011

Energy expenditure in adults living in developing compared with industrialized countries: a meta-analysis of doubly labeled water studies.

Lara R Dugas, Regina Harders, Sarah Merrill, Kara Ebersole, David A Shoham, Elaine C Rush, Felix K Assah, Terrence Forrester, Ramon A Durazo-Arvizu, Amy Luke

Registry-linked trialOpen access · bronzeAbstract readComparative StudyMeta-Analysis
In one paragraph

Synthesis in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883591 (Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty), which is not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06883591 completednot on this mapstarted 2025, after this paper: background citation

Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty: an Observational Follow-up Study 15 Years After Surgery.

TypeobservationalSponsorRijnstate HospitalRan2025 to 2026Enrolled32ConditionsTotal Hip Arthroplasty (THA), Accelerometers, Resurfacing Hip Arthroplasty
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 138 citations in OpenAlex.

  1. Do African American women require fewer calories to maintain weight?: Results from a controlled feeding trial.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2012
    Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Observational
  7. Neandertal Cold Adaptation: Technological, Anatomical, and Physiological Responses to Cold Stress in One of Our Closest Fossil Relatives.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  8. Energy expenditure and obesity across the economic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Metabolic scaling, energy allocation tradeoffs, and the evolution of humans' unique metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Sex differences and shifts in body composition, physical activity, and total energy expenditure across a 3-month expedition.American journal of human biology : the official journal of the Human Biology Council · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Lara R DugasDepartment of Preventive Medicine and Epidemiology, Loyola University Chicago, Maywood, IL 60153, USA. ldugas@lumc.edu
Regina Harders
Sarah Merrill
Kara Ebersole
David A Shoham
Elaine C Rush
Felix K Assah
Terrence Forrester
Ramon A Durazo-Arvizu
Amy Luke
Auckland University of Technology · NZMedical Research Council · GBUniversity of the West Indies System · JMAddenbrooke's Hospital · GB

Funding

ACTIVITY AND OBESITY IN US BLACK &NIGERIAN WOMENR01DK056781 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI LUKE, AMY H. · 2000 to 2004
$1.4M
NIDDK NIH HHS DK56781NIDDK NIH HHS R01 DK056781
6 · The paper itself

Abstract

backgroundThere is an assumption that people in developing countries have a higher total energy expenditure (TEE) and physical activity level (PAL) than do people in developed nations, but few objective data for this assertion exist.

objectiveWe conducted a meta-analysis of TEE and PAL by using data from countries that have a low or middle human development index (HDI) compared with those with a high HDI to better understand how energy-expenditure variables are associated with development status and population differences in body size.

designWe performed a literature search for studies in which energy expenditure was measured by using doubly labeled water. Mean data on age, weight, body mass index (BMI; in kg/m(2)), TEE, and PAL were extracted, and HDI status was assessed. Pooled estimates of the mean effect by sex were obtained, and the extent to which age, weight, HDI status, and year of publication explained heterogeneity was assessed.

resultsA total of 98 studies (14 studies from low- or middle-HDI countries) that represented 183 cohorts and 4972 individuals were included. Mean (±SE) BMI was lower in countries with a low or middle HDI than in those with a high HDI for both men and women (22.7 ± 1.0 compared with 26.0 ± 0.7, respectively, in men and 24.3 ± 0.7 compared with 26.6 ± 0.4, respectively, in women). In meta-regression models, there was an inverse association of age (P < 0.001) and a positive association of weight (P < 0.001) with TEE for both sexes; there was an association of age only in men with PAL (P < 0.001). There was no association of HDI status with either TEE or PAL.

conclusionTEE adjusted for weight and age or PAL did not differ significantly between developing and industrialized countries, which calls into question the role of energy expenditure in the cause of obesity at the population level.

Indexed as

Developed CountriesDeveloping CountriesEnergy MetabolismAdultAge FactorsBody Mass IndexBody WaterBody WeightExerciseFemaleHumansIncidenceMaleMotor ActivityObesitySex FactorsWater

Identifiers

PMID21159791
PMCPMC3021434
OpenAlexW1964146644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.