Trial reportThe American journal of psychiatry2011
Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions.
Trial report in The American journal of psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- The effects of caffeine and d-amphetamine on spatial span task in healthy participants.PloS one · 2023Trial
- Amphetamine-induced dopamine release and impulsivity in Parkinson's disease.Brain : a journal of neurology · 2022Trial
- Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism.NeuroImage. Clinical · 2016Trial
- Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Trial
- Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy.Psychopharmacology · 2013Trial
- Dexamphetamine widens temporal and spatial binding windows in healthy participants.Journal of psychiatry & neuroscience : JPNTrial
- Substance use and the value of control.Cognitive, affective & behavioral neuroscience · 2026Article
- Thoughts Falling Apart: Disorganized Schizotypy Specifically Predicts Both Psychotic- and Stress-Reactivity in Daily Life.Journal of personality · 2026Article
- SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.Schizophrenia bulletin · 2025Article
- Quantifying the effects of practicing a semantic task according to subclinical schizotypy.Scientific reports · 2024Article
- Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals.JAMA psychiatry · 2024Article
- Bayesian accounts of perceptual decisions in the nonclinical continuum of psychosis: Greater imprecision in both top-down and bottom-up processes.PLoS computational biology · 2023Article
- Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder.Journal of clinical medicine · 2021Article
- Schizotypy in Parkinson's disease predicts dopamine-associated psychosis.Scientific reports · 2021Article
- Amphetamine-induced striatal dopamine release in schizotypal personality disorder.Psychopharmacology · 2020Article
- Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [Translational psychiatry · 2019Article
- Increased resting perfusion of the hippocampus in high positive schizotypy: A pseudocontinuous arterial spin labeling study.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSchizotypal personality traits are associated with schizophrenia spectrum disorders, and individuals with schizophrenia spectrum disorders demonstrate increased dopamine transmission in the striatum. The authors sought to determine whether individual differences in normal variation in schizotypal traits are correlated with dopamine transmission in the striatum and in extrastriatal brain regions.
methodSixty-three healthy volunteers with no history of psychiatric illness completed the Schizotypal Personality Questionnaire and underwent positron emission tomography imaging with [(18)F]fallypride at baseline and after administration of oral d-amphetamine (0.43 mg/kg). Dopamine release, quantified by subtracting each participant's d-amphetamine scan from his or her baseline scan, was correlated with Schizotypal Personality Questionnaire total and factor scores using region-of-interest and voxel-wise analyses.
resultsDopamine release in the striatum was positively correlated with overall schizotypal traits. The association was especially robust in the associative subdivision of the striatum. Voxel-wise analyses identified additional correlations between dopamine release and schizotypal traits in the left middle frontal gyrus and left supramarginal gyrus. Exploratory analyses of Schizotypal Personality Questionnaire factor scores revealed correlations between dopamine release and disorganized schizotypal traits in the striatum, thalamus, medial prefrontal cortex, temporal lobe, insula, and inferior frontal cortex.
conclusionsThe association between dopamine signaling and psychosis phenotypes extends to individual differences in normal variation in schizotypal traits and involves dopamine transmission in both striatal and extrastriatal brain regions. Amphetamine-induced dopamine release may be a useful endophenotype for investigating the genetic basis of schizophrenia spectrum disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.