ArticleEuropean journal of medical research2010
Prognostic value of hedgehog signal component expressions in hepatoblastoma patients.
Article in European journal of medical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis.The American journal of pathology · 2025Article
- The Role of the Hedgehog Pathway in Cholangiocarcinoma.Cancers · 2021Review
- Molecular Mechanisms of Hepatoblastoma.Seminars in liver disease · 2021Article
- Hedgehog signalling in liver pathophysiology.Journal of hepatology · 2018Review
- Role of canonical Hedgehog signaling pathway in liver.International journal of biological sciences · 2018Review
- Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies.Frontiers in pediatrics · 2016Review
- Abnormal Hedgehog pathway in myelodysplastic syndrome and its impact on patients' outcome.Haematologica · 2015Article
- Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
- Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma.Surgery today · 2012Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveActivation of hedgehog (Hh) pathway has been implicated in the development of human malignancies. Hh as well as related downstream target genes has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. This study aimed at investigating whether Hh molecules provides a molecular marker of hepatoblastoma malignancy.
methodsWe obtained tissue sections from 32 patients with hepatoblastoma as well as cholestasis and normal control. Immunohistochemical analysis were performed to determine Hh signal components in human hepatoblastoma. The prognostic significance of single expression of Hh signal components were evaluated using Cox proportional hazards regression models and Kaplan-Meier survival analysis for statistical analysis.
resultsExpression of Hh signal components showed an increase in hepatoblastoma compared with cholestasis and normal tissues. There was a positive correlation between Smo or Gli1 expression and tumor clinicopathological features, such as histological type, tumor grade, tumor size and clinical stage. Both Smo or Gli1 protein high expression was significantly associated with poor prognosis by univariate analyses and multivariate analyses.
conclusionsAbnormal Hh signaling activation plays important roles in the malignant potential of hepatoblastoma. Gli1 expression is an independent prognostic marker.
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