ArticleBioorganic & medicinal chemistry2011
Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest.
Article in Bioorganic & medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.Bioorganic & medicinal chemistry · 2014Article
- Structure elucidation of antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri from the Madagascar dry forest.Magnetic resonance in chemistry : MRC · 2013Article
- Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges.Bioorganic & medicinal chemistry · 2013Article
- Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.Journal of natural products · 2013Article
- Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.Chemistry & biodiversity · 2013Article
- Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar rain forest.Bioorganic & medicinal chemistry · 2012Article
- Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.Journal of natural products · 2012Article
- C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.Bioorganic & medicinal chemistry · 2011Article
- Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.Bioorganic & medicinal chemistry · 2011Article
- Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest.Journal of natural products · 2011Article
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Authors and funding
11 authors.
Funding
Abstract
Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyzes of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC(50) values of 0.18, 0.21, 0.17, and 0.29μM line, and to the H460 human lung cancer cell line, with IC(50) values of 0.16, 0.68, 0.37, and 0.48μM, respectively.
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