ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2010
[The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- Elevated IL-7Rα is linked to recurrence and poorer survival of gastric adenocarcinoma.International journal of clinical and experimental pathology · 2018Article
- Potential implications of interleukin-7 in chronic wound healing.Experimental and therapeutic medicine · 2016Article
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5 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectiveit has been proven that lymph node metastasis was closely related to prognosis of lung cancer. Interleukin-7 (IL-7) and interleukin-7 receptor (IL-7R) could promote lymph node metastasis through vascular endothelial growth factor-D (VEGF-D). The aim of this study is to explore the expressions of IL-7 and IL-7R in lung cancer and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer (NSCLC).
methodsthe expressions of IL-7 and IL-7R in 95 cases of NSCLC were detected with immunohistochemistry method and the relationship between IL-7 and IL-7R and their impact on lung cancer patients' outcomes were analyzed.
resultsin 95 cases of NSCLC, the high expression rates of IL-7, IL-7R and VEGF-D were 63.16%, 61.05% and 58.95%. The expressions of IL-7 and IL-7R were correlated closely with clinic stage and lymph node metastasis, but had no relationship with age, gender, histological type and differentiation degree. The lymphatic vessel density (LVD) mean of the group with high expressions of IL-7 and IL-7R was higher than that with low or negative expressions of IL-7 and IL-7R, and they were significant different in statistics. Log-rank analysis showed that the postoperative survival period was significantly shorter in high expression groups IL-7, IL-7R and VEGF-D comparing with that in low or negative groups.
conclusionsthe high expression of IL-7 and IL-7R is highly positie correlated with clinic stage, lymph node metastasis, VEGF-D, LVD and poor prognosis in Non-small cell lung cancer.
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