ArticleExperimental dermatology2011
A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum.
Article in Experimental dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Development and In-Depth Characterization of Bacteria Repellent and Bacteria Adhesive Antibody-Coated Surfaces Using Optical Waveguide Biosensing.Biosensors · 2022Article
- Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going.Frontiers in surgery · 2022Article
- Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection.Breast cancer research : BCR · 2020Observational
- Magnetic Nanotrap Particles Preserve the Stability of Venezuelan Equine Encephalitis Virus in Blood for Laboratory Detection.Frontiers in veterinary science · 2019Article
- Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.Acta biomaterialia · 2017Article
- Immunocapture strategies in translational proteomics.Expert review of proteomics · 2016Review
- Chemokine-Releasing Nanoparticles for Manipulation of Lymph Node Microenvironment.Nanomaterials (Basel, Switzerland) · 2015Article
- A review of sentinel lymph node biopsy for thin melanoma.Irish journal of medical science · 2015Review
- Hydrogel nanoparticle harvesting of plasma or urine for detecting low abundance proteins.Journal of visualized experiments : JoVE · 2014Article
- Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society.Molecular & cellular proteomics : MCP · 2014Article
- The use of Nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells.PloS one · 2014Article
- Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay.Cancer letters · 2013Article
- Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum.Clinical biochemistry · 2013Article
- Differential denaturation of serum proteome reveals a significant amount of hidden information in complex mixtures of proteins.PloS one · 2013Article
- Substrate-baited nanoparticles: a catch and release strategy for enzyme recognition and harvesting.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Biomarkers as key contributors in treating malignant melanoma metastases.Dermatology research and practice · 2012Article
- IL-8 and cathepsin B as melanoma serum biomarkers.International journal of molecular sciences · 2011Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMelanoma represents only 4% of all skin cancers, but nearly 80% of skin cancer deaths. This manuscript applies several new measurement technologies with the purpose of elucidating molecular signatures of melanoma aggressiveness. PURPOSE: We sought to determine whether low-abundant serum proteins related to apoptotic pathways could be measured and correlated with defined melanoma subtypes. Hydrogel core shell nanoparticles, a new technology capable of selectively entrapping low molecular weight proteins and protecting them from enzymatic degradation, were used to capture candidate serum biomarkers. Biomarker levels were correlated with confocal microscopy, thereby representing a combination of new technologies for in vivo histologic documentation.
resultsAmong a panel of analyzed serum proteins, Bak was differentially expressed between nevi and melanomas. Melanomas with higher Bak serum levels exhibited more pronounced junctional activity on confocal imaging, whereas lesions with 'sparse' dermal nests had weak Bak expression.
conclusionsOur study links serum proteome analysis with confocal microscopic clinical in vivo histologic classification of melanomas. Bak has not been previously measured in serum. Bak differential expression among melanoma subtypes confirms the importance of the apoptotic pathway as a contributor to melanoma aggressiveness.
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