ArticleInternational journal of radiation biology2011
The production and composition of rat sebum is unaffected by 3 Gy gamma radiation.
Article in International journal of radiation biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
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- A scATAC-seq atlas of stasis zone in rat skin burn injury wound process.Frontiers in cell and developmental biology · 2024Article
- Metabolomics in Radiation Biodosimetry: Current Approaches and Advances.Metabolites · 2020Review
- A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury.Metabolites · 2020Review
- Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.International journal of radiation biology · 2017Review
- The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features.BBA clinical · 2017Article
- Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues.Biochimica et biophysica acta · 2016Article
- Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.Journal of radiation research · 2016Article
- Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification.Hepatology (Baltimore, Md.) · 2013Article
- Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model.Molecular bioSystems · 2013Article
- Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.Cancer research · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this work was to use metabolomics to evaluate sebum as a source of biomarkers for gamma-radiation exposure in the rat, and potentially in man. Proof of concept of radiation metabolomics was previously demonstrated in both mouse and rat urine, from the radiation dose- and time-dependent excretion of a set of urinary biomarkers. MATERIALS AND
methodsRats were gamma-irradiated (3 Gy) or sham irradiated and groups of rats were euthanised at 1 h or 24 h post-irradiation. Sebum was collected by multiple washings of the carcasses with acetone. Nonpolar lipids were extracted, methylated, separated and quantitated using gas chromatography-mass spectrometry (GCMS). Metabolomic analysis of the GCMS data was performed using both orthogonal projection to latent structures-discriminant analysis and random forests machine learning algorithm.
resultsIrradiation did not alter sebum production. A total of 35 lipids were identified in rat sebum, 29 fatty acids, five fatty aldehydes, and cholesterol. Metabolomics showed that three fatty acids, palmitic, 2-hydroxypalmitic, and stearic acids were potential biomarkers. Sebaceous palmitic acid was marginally statistically significantly elevated (7.5-8.4%) at 24 h post-irradiation.
conclusionsRat sebaceous gland appears refractory to 3 Gy gamma-irradiation. Unfortunately, collection of sebum shortly after gamma-irradiation is unlikely to form the basis of high-throughput non-invasive radiation biodosimetry in man.
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