ArticleJournal of cellular and molecular medicine2010
Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment.
Article in Journal of cellular and molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- An Enriched Primary Culture Reveals Morphological Heterogeneity of Rat Testicular Telocytes.Cells · 2026Article
- Identification and localization of telocyte-like cells in human umbilical cord stroma.Scientific reports · 2025Article
- Telocytes of the male reproductive system: dynamic tissue organizers.Frontiers in cell and developmental biology · 2024Review
- Ultrastructural evidence for telocytes in equine tendon.Journal of anatomy · 2021Article
- Immunohistochemical biomarkers and distribution of telocytes in ApoECell biology international · 2019Article
- Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle.Scientific reports · 2019Article
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Telocytes in regenerative medicine.Journal of cellular and molecular medicine · 2015Review
- Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes.PloS one · 2015Article
- Human lung telocytes could promote the proliferation and angiogenesis of human pulmonary microvascular endothelial cells in vitro.Molecular and cellular therapies · 2014Article
- Telocytes in liver: electron microscopic and immunofluorescent evidence.Journal of cellular and molecular medicine · 2013Article
- Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction (Cambridge, England) · 2013Article
- Immunolocalization and expression of small-conductance calcium-activated potassium channels in human myometrium.Journal of cellular and molecular medicine · 2012Article
- Telocytes in the human kidney cortex.Journal of cellular and molecular medicine · 2012Article
- Telocytes in the urinary system.Journal of translational medicine · 2012Article
- Cardiac telocytes - their junctions and functional implications.Cell and tissue research · 2012Article
- Platelet-derived growth factor receptor-β-positive telocytes in skeletal muscle interstitium.Journal of cellular and molecular medicine · 2012Article
- The primary cilium of telocytes in the vasculature: electron microscope imaging.Journal of cellular and molecular medicine · 2011Article
- Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.Journal of cellular and molecular medicine · 2011Article
- Telocytes in trachea and lungs.Journal of cellular and molecular medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the presence of telocytes was demonstrated in human and mammalian tissues and organs (digestive and extra-digestive organs, genitourinary organs, heart, placenta, lungs, pleura, striated muscle). Noteworthy, telocytes seem to play a significant role in the normal function and regeneration of myocardium. By cultures of telocytes in two- and three-dimensional environment we aimed to study the typical morphological features as well as functionality of telocytes, which will provide important support to understand their in vivo roles. Neonatal rat cardiomyocytes were isolated and cultured as seeding cells in vitro in two-dimensional environment. Furthermore, engineered myocardium tissue was constructed from isolated cells in three-dimensional collagen/Matrigel scaffolds. The identification of telocytes was performed by using histological and immunohistochemical methods. The results showed that typical telocytes are distributed among cardiomyocytes, connecting them by long telopodes. Telocytes have a typical fusiform cell body with two or three long moniliform telopodes, as main characteristics. The vital methylene blue staining showed the existence of telocytes in primary culture. Immunohistochemistry demonstrated that some c-kit or CD34 immuno-positive cells in engineered heart tissue had the morphology of telocytes, with a typical fusiform cell body and long moniliform telopodes. Also, a significant number of vimentin+ telocytes were present within engineered heart tissue. We suggest that the model of three-dimensional engineered heart tissue could be useful for the ongoing research on the functional relationships of telocytes with cardiomyocytes. Because the heart has the necessary potential of changing the muscle and non-muscle cells during the lifetime, telocytes might play an active role in the heart regeneration process. Moreover, telocytes might be a useful tool for cardiac tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.