ArticleEpilepsy currents2010
An update on antiepileptic drugs and suicide: are there definitive answers yet?
Article in Epilepsy currents, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Trigeminal neuralgia is associated with increased risk of cerebrovascular disease, myocardial infarction and suicide - a nationwide Swedish study.The journal of headache and pain · 2026Article
- Psychiatric and behavioural side effects of antiseizure medications in epilepsy.Journal of neurology · 2025Review
- Is Topiramate Helpful in the Management of Cocaine Use-Related Psychiatric Comorbidities?Cureus · 2025Article
- Article
- Risk of Suicidal Ideation and Behavior Following Early-Onset Idiopathic Restless Legs Syndrome Treatment.Pharmacoepidemiology and drug safety · 2024Article
- Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England.The Lancet regional health. Europe · 2023Article
- [Depression in patients with epilepsy. Pathophysiological and clinical concepts and therapeutic strategies].Revista de neurologia · 2023Review
- Optimization of Therapy in Patients with Epilepsy and Psychiatric Comorbidities: Key Points.Current neuropharmacology · 2023Article
- Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities.Neurochemical research · 2021Review
- SNI case of the week: Initial concomitant use of gabapentin, clonidine, and prednisone may enhance suicidal ideation: A case report.Surgical neurology international · 2020Article
- Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden.BMJ (Clinical research ed.) · 2019Article
- Gabapentin-related suicide: Myth or fact?Surgical neurology international · 2018Article
- Understanding epigenetic architecture of suicide neurobiology: A critical perspective.Neuroscience and biobehavioral reviews · 2017Review
- Management of psychiatric and neurological comorbidities in epilepsy.Nature reviews. Neurology · 2016Review
- Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior.Neurology · 2013Article
- Mortality risks in new-onset childhood epilepsy.Pediatrics · 2013Article
- Are antiepileptic drugs used in the treatment of migraine associated with an increased risk of suicidality?Current pain and headache reports · 2011Review
- Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence.Drug, healthcare and patient safety · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2008, the Food and Drug Administration (FDA) issued a warning that any and all antiepileptic drugs (AEDs) might increase the risk of suicidal ideation, suicide attempt, and completed suicide. Considerable confusion and concern followed regarding the use of these drugs, in general, and specifically for people with epilepsy. Recently, four publications examined suicidality and AED use among several databases and illustrated how biases affect the findings. None of the studies was able to control completely for the indication for which the AEDs were prescribed or to account for the varying intensities with which different specialists monitoring patients for suicidality. Though multiple analyses were conducted for many AEDs, no study controlled for the numerous comparisons made. The result is a multitude of contradictions in the findings across studies and even within studies, with no study providing clear or convincing support for the FDA conclusions. This review attempts to clarify the methodological issues in assessing potential associations between AED use and suicidality.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.