ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Adherence to Animal Research: Reporting of In Vivo Experiments Guidelines in Stem Cell Studies in Animal Models of Parkinson's Disease: A Systematic Review.Yonsei medical journal · 2025Pooled it
- The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth.Environmental health perspectives · 2014Pooled it
- The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes.Environmental health perspectives · 2014Pooled it
- Instruments for assessing risk of bias and other methodological criteria of published animal studies: a systematic review.Environmental health perspectives · 2013Pooled it
- A systematic review of exercise training to promote locomotor recovery in animal models of spinal cord injury.Journal of neurotrauma · 2012Pooled it
- Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan.Environment internationalPooled it
- CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study.Journal of translational medicine · 2013Trial
- Improving the transparency of animal experiments: valuable lessons learned from a systematic analysis of registration protocols.BMC veterinary research · 2026Article
- CRIME-Q-a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research.BMC medical research methodology · 2024Article
- Identifying assessment criteria for in vitro studies: a method and item bank.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Article
- Experimental replications in animal trials.Laboratory animals · 2021Article
- Comparative Analysis of Web of Science and Pubmed Indexed Medical Journals Published in Former Yugoslav Countries.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- Methodological Errors in Clinical Studies Published by Medical Journals of Ex-Yugoslav Countries.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Article
- Evaluation of Preclinical and Clinical Studies Published in Medical Journals of Bosnia and Herzegovina: Methodology Issues.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Article
- Evaluation of Published Preclinical Experimental Studies in Medicine: Methodology Issues.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Article
- Disbiome database: linking the microbiome to disease.BMC microbiology · 2018Article
- Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease.PloS one · 2017Article
- Editorial: Reporting guidelines for psychopharmacology.Psychopharmacology · 2016Article
Corrections and comments
- Erratum issuedVesterinen, Hanna V [corrected to Vesterinen, Hanna M]
Authors and funding
7 authors.
Funding
Abstract
Translating experimental findings into clinically effective therapies is one of the major bottlenecks of modern medicine. As this has been particularly true for cerebrovascular research, attention has turned to the quality and validity of experimental cerebrovascular studies. We set out to assess the study design, statistical analyses, and reporting of cerebrovascular research. We assessed all original articles published in the Journal of Cerebral Blood Flow and Metabolism during the year 2008 against a checklist designed to capture the key attributes relating to study design, statistical analyses, and reporting. A total of 156 original publications were included (animal, in vitro, human). Few studies reported a primary research hypothesis, statement of purpose, or measures to safeguard internal validity (such as randomization, blinding, exclusion or inclusion criteria). Many studies lacked sufficient information regarding methods and results to form a reasonable judgment about their validity. In nearly 20% of studies, statistical tests were either not appropriate or information to allow assessment of appropriateness was lacking. This study identifies a number of factors that should be addressed if the quality of research in basic and translational biomedicine is to be improved. We support the widespread implementation of the ARRIVE (Animal Research Reporting In Vivo Experiments) statement for the reporting of experimental studies in biomedicine, for improving training in proper study design and analysis, and that reviewers and editors adopt a more constructively critical approach in the assessment of manuscripts for publication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.