ReviewCurrent opinion in organ transplantation2011
Platelets: versatile modifiers of innate and adaptive immune responses to transplants.
Review in Current opinion in organ transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Levels of Talin1 in Platelet-Derived Microvesicles Affect Platelet Activation in Patients with Nonvalvular Atrial Fibrillation.Biochemical genetics · 2026Article
- Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review.Biomedicines · 2024Review
- Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo.Journal of fungi (Basel, Switzerland) · 2023Article
- Assessment of Oxidative Stress Markers in Hypothermic Preservation of Transplanted Kidneys.Antioxidants (Basel, Switzerland) · 2021Article
- Generation and Characterization of a New Monoclonal Antibody Against CXCL4.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2015Article
- Platelets: at the nexus of antimicrobial defence.Nature reviews. Microbiology · 2014Review
- Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.The Journal of clinical investigation · 2014Article
- An unexpected role for platelets in blocking Th17 differentiation.The Journal of clinical investigation · 2014Article
- Alloantibody induced platelet responses in transplants: potent mediators in small packages.Human immunology · 2012Review
- Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum.Seminars in immunopathology · 2012Review
- The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury.PloS one · 2012Article
- Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewOver the last decade there has been mounting experimental data demonstrating that platelets contribute to acute vascular inflammation and atherosclerosis. This review focuses on recent findings that link platelets to inflammatory responses of relevance to transplants. RECENT
findingsAlthough it has been known that platelets modify vascular inflammation by secretion of soluble mediators and release of microparticles, new aspects of these mechanisms are being defined. For example, platelet-derived CCL5 not only functions in homomers, but also forms more potent heteromers with platelet factor 4 (PF4; CXCL4). This heteromer formation can be inhibited with small molecules. New findings also demonstrate heterologous interactions of platelet microparticles with leukocytes that may increase their range of impact. By attaching to neutrophils, platelet microparticles appear to migrate out of blood vessels and into other compartments where they stimulate secretion of cytokines. Contact of platelets with extracellular matrix also can result in cleavage of hyaluronan into fragments that serve as an endogenous danger signal. SUMMARY: Recent findings have expanded the range of interactions by which platelets can modify innate and adaptive immune responses to transplants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.