ArticlePhysiological genomics2011
Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Motus Vita Est: Fruit Flies Need to Be More Active and Sleep Less to Adapt to Either a Longer or Harder Life.Clocks & sleep · 2023Article
- Effects of physical exercise on muscle metabolism and meat quality characteristics of Mongolian sheep.Food science & nutrition · 2022Article
- Physical Activity Engagement Worsens Health Outcomes and Limits Exercise Capacity in Growth-restricted Mice.Medicine and science in sports and exercise · 2021Article
- Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine Model.Frontiers in psychiatry · 2021Article
- Inferring Relationship of Blood Metabolic Changes and Average Daily Gain With Feed Conversion Efficiency in Murrah Heifers: Machine Learning Approach.Frontiers in veterinary science · 2020Article
- Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis.The Journal of physiology · 2018Article
- CC002/Unc females are mouse models of exercise-induced paradoxical fat response.Physiological reports · 2018Article
- Long-term exercise in mice has sex-dependent benefits on body composition and metabolism during aging.Physiological reports · 2016Article
- Hormones and the Evolution of Complex Traits: Insights from Artificial Selection on Behavior.Integrative and comparative biology · 2016Review
- The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.Reproduction (Cambridge, England) · 2016Article
- Preclinical mouse models for assessing axial compression of long bones during exercise.BoneKEy reports · 2015Article
- Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice.BioMed research international · 2015Article
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Article
- The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.Endocrinology · 2013Article
- Article
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
- Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice.Physiological genomics · 2012Article
- Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain.Genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The regulation of body weight and composition is complex, simultaneously affected by genetic architecture, the environment, and their interactions. We sought to analyze the complex phenotypic relationships between voluntary exercise, food consumption, and changes in body weight and composition and simultaneously localize quantitative trait loci (QTL) controlling these traits. A large (n = 815) murine advanced intercross line (G(4)) was created from a reciprocal cross between a high-running line and the inbred strain C57BL/6J. Body weight and composition (% fat, % lean) were measured at 4, 6, and 8 wk of age. After measurements at 8 wk of age, mice were given access to running wheels, during which food consumption was quantified and after which body weight and composition were assessed to evaluate exercise-induced changes. Phenotypic correlations indicated that the relationship between exercise and overall change in weight and adiposity depended on body composition before the initiation of exercise. Interval mapping revealed QTL for body weight, % fat, and % lean at 4, 6, and 8 wk of age. Furthermore, QTL were observed for food consumption and changes in weight, % fat, and % lean in response to short-term exercise. Here we provide some clarity for the relationship between weight loss, reduction in adiposity, food consumption, and exercise. Simultaneously, we reinforce the genetic basis for body weight and composition with some independent loci controlling growth at different ages. Finally, we present unique QTL providing insight regarding variation in weight loss and reduction in adiposity in response to exercise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.