SynthesisAmerican journal of epidemiology2011
Ischemic heart disease mortality and morbidity rates in former drinkers: a meta-analysis.
Synthesis in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The Effect of Alcohol on Blood Pressure and Hypertension.Current hypertension reports · 2021Pooled it
- Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality.PLoS biology · 2018Pooled it
- The relationship between different dimensions of alcohol use and the burden of disease-an update.Addiction (Abingdon, England) · 2017Pooled it
- Alcohol Consumption and Mortality From Coronary Heart Disease: An Updated Meta-Analysis of Cohort Studies.Journal of studies on alcohol and drugs · 2017Pooled it
- Pooled it
- The cardioprotective association of average alcohol consumption and ischaemic heart disease: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2012Pooled it
- Pooled it
- Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.BMJ (Clinical research ed.) · 2017Trial
- A Practical Guide to Conducting Dose-Response Meta-Analyses in Epidemiology.Methodology : European journal of research methods for the behavioral & social sciences · 2025Article
- Differential Associations of Alcohol Use With Ischemic Heart Disease Mortality by Socioeconomic Status in the US, 1997-2018.JAMA network open · 2024Article
- The association between population drinking and ischemic heart disease mortality in educational groups.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Association of alcohol consumption with the prevalence and various stages of chronic kidney disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Observational
- Physical activity and substance use among Canadian adolescents: Examining the moderating role of school connectedness.Frontiers in public health · 2022Article
- The impact of removing former drinkers from genome-wide association studies of AUDIT-C.Addiction (Abingdon, England) · 2021Article
- Alcohol, cardiovascular disease and industry funding: A co-authorship network analysis of systematic reviews.Social science & medicine (1982) · 2021Article
- Alcohol's Impact on the Cardiovascular System.Nutrients · 2021Review
- Review
- Patterns of Alcohol Consumption in the PURE Poland Cohort Study and Their Relationship with Health Problems.International journal of environmental research and public health · 2021Article
- A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.PLoS genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Current abstainers from alcohol have been identified as an inadequate reference group in epidemiologic studies of the effects of alcohol, because inclusion of former drinkers might lead to overestimation of the protective effects and underestimation of the detrimental effects of drinking alcohol. The authors' objective in the current study was to quantify this association for ischemic heart disease (IHD). Electronic databases were systematically searched for relevant case-control or cohort studies published from 1980 to 2010. Thirty-eight articles fulfilled the inclusion criteria, contributing a total of 5,613 IHD events and 12,097 controls among case-control studies and 1,387 events with combined endpoints and 7,183 events stratified by endpoint among 232,621 persons at risk among cohort studies. Pooled estimates for the subset stratified by sex and endpoint showed a significantly increased risk among former drinkers compared with long-term abstainers for IHD mortality ( among men; relative risk = 1.25, 95% confidence interval: 1.15, 1.36; among women relative risk = 1.54, 95% confidence interval: 1.17, 2.03). For IHD morbidity, the estimates for both sexes were close to unity and not statistically significant. Results were robust in several sensitivity analyses. In future studies, researchers should separate former drinkers from the reference category to obtain unbiased effect estimates. Implications for the overall beneficial and detrimental effects of alcohol consumption on IHD are discussed below.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.