Evidence map›Paper›PMID 21156363›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2010

Noninvasive thermometry assisted by a dual-function ultrasound transducer for mild hyperthermia.

Chun-Yen Lai, Dustin E Kruse, Charles F Caskey, Douglas N Stephens, Patrick L Sutcliffe, Katherine W Ferrara

Abstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Image-Based Monitoring of Thermal Ablation.Bioengineering (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Thermometry and ablation monitoring with ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2015
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chun-Yen LaiUniversity of California at Davis, Department of Biomedical Engineering, Davis, CA, USA.
Dustin E Kruse
Charles F Caskey
Douglas N Stephens
Patrick L Sutcliffe
Katherine W Ferrara

Funding

Ultrasound Imaging and Local Drug Delivery in TumorsR01CA103828 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI FERRARA, KATHERINE W · 2004 to 2013
$10.4M
Specific and high-resolution ultrasound cancer imagingR01CA112356 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI FERRARA, KATHERINE W, FOIRET, JOSQUIN · 2005 to 2022
$6.1M
Ultrasound imaging and enhanced therapeutic responseR01CA134659 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2009 to 2017
$4.4M
Toward real-time prediction and validation of ultrasonic hyperthermia profilesR21EB009434 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W, KRUSE, DUSTIN EDWARD · 2009 to 2010
$504k
NCI NIH HHS CA103828NCI NIH HHS R01 CA103828NCI NIH HHS R01 CA112356NCI NIH HHS R01 CA134659NIBIB NIH HHS EB009434NIBIB NIH HHS R21 EB009434
6 · The paper itself

Abstract

Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was 1.9 to 4.5°C without correction compared with 1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system.

Indexed as

Signal Processing, Computer-AssistedAlgorithmsAnimalsBreast NeoplasmsFemaleHyperthermia, InducedImage Processing, Computer-AssistedMiceNeoplasm TransplantationPhantoms, ImagingSepharoseTemperatureThermographyTransducersUltrasonographySepharose

Identifiers

PMID21156363
PMCPMC3018687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.