ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2010
Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 122 citations in OpenAlex.
- MR-based skull parametric modeling for blood-brain barrier opening in non-human primates.Scientific reports · 2026Article
- Article
- Numerical Validation of mSOUND Using Fully Heterogeneous Skull Models.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2026Article
- Flexible ultrasound array for subcortical brain stimulation in humans: a simulation study.NPJ acoustics · 2026Article
- Blood‒brain barrier opening with Golay-coded ultrasound to improve therapeutic consistency in glioblastoma models.Drug delivery · 2025Article
- Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation.Nature communications · 2025Article
- A comparative study of experimental and simulated ultrasound beam propagation through cranial bones.Physics in medicine and biology · 2025Article
- Treatment envelope of transcranial histotripsy: challenges and strategies to maximize the treatment location profile.Physics in medicine and biology · 2024Article
- Feasibility of Hologram-Assisted Bilateral Blood-Brain Barrier Opening in Non-Human Primates.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Robust deep learning estimation of cortical bone porosity from MR T1-weighted images for individualized transcranial focused ultrasound planning.medRxiv : the preprint server for health sciences · 2024Article
- Focused ultrasound heating in brain tissue/skull phantoms with 1 MHz single-element transducer.Journal of ultrasound · 2024Article
- Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation.Scientific reports · 2023Article
- Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico.IEEE transactions on bio-medical engineering · 2023Article
- Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure.bioRxiv : the preprint server for biology · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
- Harnessing Ultrasound for Targeting Drug Delivery to the Brain and Breaching the Blood-Brain Tumour Barrier.Pharmaceutics · 2022Review
- Classical and Learned MR to Pseudo-CT Mappings for Accurate Transcranial Ultrasound Simulation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound.Scientific reports · 2022Article
- Numerical Evaluation of the Effects of Transducer Displacement on Transcranial Focused Ultrasound in the Rat Brain.Brain sciences · 2022Article
- S.M.A.R.T. F.U.S: Surrogate Model of Attenuation and Refraction in Transcranial Focused Ultrasound.PloS one · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this paper, we investigate the focalization properties of single-element transducers at low frequencies (300 to 1000 kHz) through primate and human skulls. The study addresses the transcranial targeting involved in ultrasound- induced blood-brain barrier (BBB) opening with clinically relevant targets such as the hippocampus and the basal ganglia, which are typically affected by early Alzheimer's and Parkinson's disease, respectively. A finite-difference, timedomain simulation platform is used to solve the 3-D linear acoustic wave equation with CT-based acoustic maps of the skulls. The targeted brain structures were extracted from 3-D brain atlases registered with the skulls and used to virtually position and orient the transducers. The effect of frequency is first investigated and the targeting of the different structures is then tested. The frequency of 500 kHz provided the best tradeoff between phase aberrations and standing wave effects in the human case, whereas the frequency of 800 kHz was most suitable in the case of the primate skull. A fast periodic linear chirp method was developed and found capable of reducing the standing wave effects. Such a simple, affordable, and convenient system is concluded to be feasible for BBB opening in primates and humans and could thus allow for its broader impact and applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.