Trial reportAtherosclerosis2011
Oxidized LDL immune complexes and coronary artery calcification in type 1 diabetes.
Trial report in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Immune Complexes and the Risk of CVD in Type 1 Diabetes.Diabetes · 2019Trial
- Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D.Journal of lipid research · 2019Trial
- Trial
- The levels of MDA-LDL in circulating immune complexes predict myocardial infarction in the VADT study.Atherosclerosis · 2012Trial
- Article
- Effects of oxidized LDL versus IL-1ß/TNF-ɑ/INFɣ on human gingival mesenchymal stem cells properties.Journal of periodontal research · 2025Article
- Cut-off value of serum homocysteine in relation to increase of coronary artery calcification.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Article
- Establishment and evaluation of a general dissociation technique for antibodies in circulating immune complexes.Clinical and experimental medicine · 2019Article
- Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling.Journal of nutrition and metabolism · 2018Review
- Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction.PloS one · 2018Article
- Severe hypoglycemia and coronary artery calcification during the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study.Diabetes research and clinical practice · 2015Article
- Modified low density lipoprotein and lipoprotein-containing circulating immune complexes as diagnostic and prognostic biomarkers of atherosclerosis and type 1 diabetes macrovascular disease.International journal of molecular sciences · 2014Review
- Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Relationship between oxidized low-density lipoprotein antibodies and obesity in different glycemic situations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Article
- Modified Lipoproteins in Diabetic Retinopathy: A Local Action in the Retina.Journal of clinical & experimental ophthalmology · 2013Article
- Oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes.Atherosclerosis · 2013Article
- Diabetes alters activation and repression of pro- and anti-inflammatory signaling pathways in the vasculature.Frontiers in endocrinology · 2013Article
- The Pathogenic Role of the Adaptive Immune Response to Modified LDL in Diabetes.Frontiers in endocrinology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveOxidized LDL (oxLDL) and oxLDL antibodies form immune complexes (IC) that reflect essential components in the development of atherosclerosis: dyslipidemia, oxidative stress and induction of a pro-inflammatory humoral immune response. We measured oxLDL in IC (oxLDL-IC) isolated from patients with type 1 diabetes to assess the relationship between oxLDL-IC and coronary artery calcification (CAC).
methodsOxLDL was measured in IC isolated from baseline samples from a subgroup of 476 patients of the Diabetes Control and Complications Trial (DCCT). CAC was determined by computed tomography (CT) 11-20 years later. Multivariable log-binomial regression models were used to estimate the risk ratios associated with having a high CAC score with an increase of 1 standard deviation (SD) of the natural logarithm of oxLDL-IC.
resultsMultivariable regression models indicate that a 1 SD increase in the levels of oxLDL-IC was associated with a 37% increase in the risk of having high CAC score (RR=1.36; 95% CI: 1.12-1.67) at follow-up after adjustment for DCCT treatment group, retinopathy/AER groups, gender and CT scanning site as well as baseline age, diabetes duration and HbA1C %. Further adjustment for smoking status, blood pressure and LDL resulted in a risk ratio of 1.23 (95% CI: 1.01-1.50) which remained statistically significant indicating that baseline oxLDL-IC is independently associated with the development of CAC. DISCUSSION: Increased levels of oxLDL-IC are associated with the development of coronary calcification. This observation reinforces previously published clinical and experimental data demonstrating that oxLD-IC has pro-inflammatory and proatherogenic properties.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.