ArticleJournal of the American Academy of Child and Adolescent Psychiatry2011
Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Role of Ash1l in Tourette syndrome and other neurodevelopmental disorders.Developmental neurobiology · 2021Pooled it
- Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder.Journal of child and adolescent psychopharmacology · 2015Trial
- Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026Article
- Early developmental milestones associated with tics and psychopathological comorbidity: An EMTICS study.European child & adolescent psychiatry · 2025Observational
- Identifying Distinct Tourette Disorder Subtypes using Clinical Data.medRxiv : the preprint server for health sciences · 2025Article
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
- Symptom Network Analysis in a Large Sample of Children and Adults with a Chronic Tic Disorder.Movement disorders clinical practice · 2024Article
- Developing a phenotype risk score for tic disorders in a large, clinical biobank.Translational psychiatry · 2024Article
- Emotion regulation and tic disorders in children.European child & adolescent psychiatry · 2023Article
- Co-Occurrence of Tic Disorders and Attention-Deficit/Hyperactivity Disorder-Does It Reflect a Common Neurobiological Background?Biomedicines · 2022Review
- Article
- White matter alterations in drug-naïve children with Tourette syndrome and obsessive-compulsive disorder.Frontiers in neurology · 2022Article
- Trends of Tourette Syndrome in children from 2011 to 2021: A bibliometric analysis.Frontiers in behavioral neuroscience · 2022Article
- Genetics of obsessive-compulsive disorder.Psychological medicine · 2021Review
- A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021Review
- Psychiatric genetics and the structure of psychopathology.Molecular psychiatry · 2019Review
- Transcranial Magnetic Stimulation in Tourette Syndrome: A Historical Perspective, Its Current Use and the Influence of Comorbidities in Treatment Response.Brain sciences · 2018Review
- Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.European child & adolescent psychiatry · 2018Article
- Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome.Psychological medicine · 2018Article
- Progress in Genetic Studies of Tourette's Syndrome.Brain sciences · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTourette syndrome (TS) is a neuropsychiatric disorder with a genetic component that is highly comorbid with obsessive-compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD). However, the genetic relations between these disorders have not been clearly elucidated. This study examined the familial relations among TS, OCD, and ADHD in a large sample of TS families.
methodParent-offspring concordance of TS, OCD, and ADHD was examined in 952 individuals from 222 TS-affected sib-pair families originally collected for genetic studies using logistic regression with generalized estimating equations to control for correlated data. Variance components methods were used to estimate the heritability and genetic and environmental correlations among TS, OCD, and ADHD. Bilineal families where both parents had TS or OCD were excluded.
resultsOCD and ADHD were highly heritable in these TS families. There were significant genetic correlations between TS and OCD and between OCD and ADHD, but not between TS and ADHD. In addition, significant environmental correlations were found between TS and ADHD and between OCD and ADHD. Parental OCD + ADHD was associated with offspring OCD + ADHD.
conclusionsThis study provides further evidence for a genetic relation between TS and OCD and suggests that the observed relation between TS and ADHD may due in part be to a genetic association between OCD and ADHD and in part due to shared environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.