ArticleBiophysical journal2010
Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain.Nature metabolism · 2024Article
- Integration of nuclear CaCellular and molecular life sciences : CMLS · 2023Article
- The evolution of organellar calcium mapping technologies.Cell calcium · 2022Review
- Review of data processing of functional optical microscopy for neuroscience.Neurophotonics · 2022Review
- Real-time imaging ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Generation and Characterization of a New FRET-Based CaInternational journal of molecular sciences · 2021Article
- RyR-mediated CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health.Journal of cell science · 2021Review
- Review
- Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator.Neuron · 2020Article
- Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity.Cold Spring Harbor perspectives in biology · 2020Review
- Wide-Area All-Optical Neurophysiology in Acute Brain Slices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Epigenome Interactions with Patterned Neuronal Activity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Regulated transport of signaling proteins from synapse to nucleus.Current opinion in neurobiology · 2017Review
- Reciprocal Interaction of Dendrite Geometry and Nuclear Calcium-VEGFD Signaling Gates Memory Consolidation and Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Exploring cells with targeted biosensors.The Journal of general physiology · 2017Review
- Nuclear calcium is required for human T cell activation.The Journal of cell biology · 2016Article
- Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging.Biophysical journal · 2016Review
- Grabbing brain activity on the go.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation: IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING.The Journal of biological chemistry · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear calcium is a key signal in the dialogue between synapse and nucleus that controls the genomic responses required for persistent adaptations, including memory and acquired neuroprotection. The amplitude and duration of nuclear calcium transients specify activity-induced transcriptional changes. However, the precise relationship between synaptic input and nuclear calcium output is unknown. Here, we used stereotaxic delivery to the rat brain of recombinant adeno-associated viruses encoding nuclear-targeted calcium sensors to assess nuclear calcium transients in CA1 pyramidal neurons after stimulation of the Schaffer collaterals. We show that in acute hippocampal slices, a burst of synaptic activity elicits a nuclear calcium signal with a regenerative component at above-threshold stimulation intensities. Using classical stimulation paradigms (i.e., high-frequency stimulation (HFS) and θ burst stimulation (TBS)) to induce early LTP (E-LTP) and transcription-dependent late LTP (L-LTP), we found that the magnitude of nuclear calcium signals and the number of action potentials activated by synaptic stimulation trains are greatly amplified by their repetition. Nuclear calcium signals and action potential generation were reduced by blockade of either NMDA receptors or L-type voltage-gated calcium channels, but not by procedures that lead to internal calcium store depletion or by blockade of metabotropic glutamate receptors. These findings identify a repetition-induced switch in nuclear calcium signaling that correlates with the transition from E-LTP to L-LTP, and may explain why the transcription-dependent phase of L-LTP is not induced by a single HFS or TBS but requires repeated trains of activity. Recombinant, nuclear-targeted indicators may prove useful for further analysis of nuclear calcium signaling in vivo.
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