ArticleBiophysical journal2010
Mechanical response and conformational amplification in α-helical coiled coils.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases.Nature chemistry · 2024Article
- Mechanical Behavior of Octopus Egg Tethers Composed of Topologically Constrained, Tandemly Repeated EGF Domains.Biomacromolecules · 2023Article
- Evidence for S2 flexibility by direct visualization of quantum dot-labeled myosin heads and rods within smooth muscle myosin filaments moving on actin in vitro.The Journal of general physiology · 2021Article
- Bioinspired Suprahelical Frameworks as Scaffolds for Artificial Photosynthesis.ACS applied materials & interfaces · 2020Article
- Article
- Molecular mechanics of coiled coils loaded in the shear geometry.Chemical science · 2018Article
- Origins of chemoreceptor curvature sorting in Escherichia coli.Nature communications · 2017Article
- F1 rotary motor of ATP synthase is driven by the torsionally-asymmetric drive shaft.Scientific reports · 2016Article
- Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.Cell reports · 2016Article
- The twisted tauopathies: surface interactions of helically patterned filaments seen in alzheimer's disease and elsewhere.Soft matter · 2016Article
- The winch model can explain both coordinated and uncoordinated stepping of cytoplasmic dynein.Biophysical journal · 2014Article
- Hierarchical cascades of instability govern the mechanics of coiled coils: helix unfolding precedes coil unzipping.Biophysical journal · 2014Article
- A mechanochemical model of actin filaments.Biophysical journal · 2012Article
- Physics of bacterial morphogenesis.Microbiology and molecular biology reviews : MMBR · 2011Review
- Hysteresis-based mechanism for the directed motility of the Ncd motor.Biophysical journal · 2011Article
- Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
α-Helical coiled coils (CCs) are ubiquitous tertiary structural domains that are often found in mechanoproteins. CCs have mechanical rigidity and are often involved in force transmission between protein domains. Although crystal structures of CCs are available, information about their conformational flexibility is limited. The role of hydrophobic interactions in determining the CC conformation is not clear. In this work we examined the mechanical responses of typical CCs and constructed a coarse-grained mechanical model to describe the conformation of the protein. The model treats α-helices as elastic rods. Hydrophobic bonds arranged in a repeated pattern determine the CC structure. The model is compared with molecular-dynamics simulations of CCs under force. We also estimate the effective bending and twisting persistence length of the CC. The model allows us to examine unconventional responses of the CC, including significant conformational amplification upon binding of a small molecule. We find that the CC does not behave as a simple elastic rod and shows complex nonlinear responses. These results are significant for understanding the role of CC structures in chemoreceptors, motor proteins, and mechanotransduction in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.