ArticleClinical and experimental immunology2011
Interference of Bifidobacterium choerinum or Escherichia coli Nissle 1917 with Salmonella Typhimurium in gnotobiotic piglets correlates with cytokine patterns in blood and intestine.
Article in Clinical and experimental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Protective Effect ofMicroorganisms · 2026Article
- Major Foodborne Bacterial Pathogens in Poultry: Implications for Human Health and the Poultry Industry and Probiotic Mitigation Strategies.Microorganisms · 2025Review
- Bacterial microcompartment utilization in the human commensalJournal of bacteriology · 2024Article
- Priority order of neonatal colonization by a probiotic or pathogenicFrontiers in microbiology · 2024Article
- Commensal Bacteria Impact on Intestinal Toll-like Receptor Signaling inPathogens (Basel, Switzerland) · 2023Article
- Defined Pig Microbiota with a Potential Protective Effect against Infection withMicroorganisms · 2023Article
- Effect of Probiotic E. coli Nissle 1917 Supplementation on the Growth Performance, Immune Responses, Intestinal Morphology, and Gut Microbes of Campylobacter jejuni Infected Chickens.Infection and immunity · 2022Article
- Article
- Review
- Monoassociation of Preterm Germ-Free Piglets withBiomedicines · 2021Article
- Colonization of Germ-Free Piglets with Mucinolytic and Non-MucinolyticMicroorganisms · 2020Article
- Toll-Like Receptor 4 Signaling in the Ileum and Colon of Gnotobiotic Piglets Infected withToxins · 2020Article
- Chlamydia suis is associated with intestinal NF-κB activation in experimentally infected gnotobiotic piglets.Pathogens and disease · 2020Article
- Colonization of Germ-Free Piglets with CommensalMicroorganisms · 2019Article
- Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG and its interference with Salmonella Typhimurium.Clinical and experimental immunology · 2019Article
- Investigation of Microbiota Alterations and Intestinal Inflammation Post-Spinal Cord Injury in Rat Model.Journal of neurotrauma · 2018Article
- The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation.Nutrients · 2018Review
- Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota.Scientific reports · 2017Article
- Unraveling the Differences between Gram-Positive and Gram-Negative Probiotics in Modulating Protective Immunity to Enteric Infections.Frontiers in immunology · 2017Review
- Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK-cell responses.European journal of immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The colonization, translocation and protective effect of two intestinal bacteria - PR4 (pig commensal strain of Bifidobacterium choerinum) or EcN (probiotic Escherichia coli strain Nissle 1917) - against subsequent infection with a virulent LT2 strain of Salmonella enterica serovar Typhimurium were studied in gnotobiotic pigs after oral association. The clinical state of experimental animals correlated with bacterial translocation and levels of inflammatory cytokines [a chemokine, interleukin (IL)-8, a proinflammatory cytokine, tumour necrosis factor (TNF)-α and an anti-inflammatory cytokine, IL-10] in plasma and intestinal lavages. Gnotobiotic pigs orally mono-associated with either PR4 or EcN thrived, and bacteria were not found in their blood. No significant inflammatory cytokine response was observed. Mono-association with Salmonella caused devastating septicaemia characterized by high levels of IL-10 and TNF-α in plasma and TNF-α in the intestine. Di-associated gnotobiotic pigs were given PR4 or EcN for 24 h. Subsequently, they were infected orally with Salmonella and euthanized 24 h later. Pigs associated with bifidobacteria before Salmonella infection suffered from severe systemic infection and mounted similar cytokine responses as pigs infected with Salmonella alone. In contrast, EcN interfered with translocation of Salmonella into mesenteric lymph nodes and systemic circulation. Pigs pre-associated with EcN thrived and their clinical condition correlated with the absence of IL-10 in their plasma and a decrease of TNF-α in plasma and ileum.
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