ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2011
Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis.Archives of microbiology · 2024Review
- Type 2 chronic inflammatory diseases: targets, therapies and unmet needs.Nature reviews. Drug discovery · 2023Review
- Article
- [Dysbalance between the immune system and skin microbiome in chronic inflammatory dermatoses].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Review
- IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4Scientific reports · 2021Article
- The Role of Atopy in COPD and Asthma.Frontiers in medicine · 2021Review
- Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.Frontiers in immunology · 2021Review
- Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice.European journal of nutrition · 2020Article
- Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype.The Journal of investigative dermatology · 2018Observational
- The Role of Immune Defects and Colonization ofAnalytical cellular pathology (Amsterdam) · 2018Review
- Article
- Molecular aspects of allergens in atopic dermatitis.Current opinion in allergy and clinical immunology · 2017Review
- The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation.Scientific reports · 2017Article
- The influence of skin microorganisms on cutaneous immunity.Nature reviews. Immunology · 2016Review
- Functional Gastrointestinal Symptoms Are Associated with Higher Serum Total IgE Levels, but Less Atopic Sensitization.Digestive diseases and sciences · 2016Article
- [Adaptive immune response and associated trigger factors in atopic dermatitis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015Article
- Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways.PloS one · 2015Article
- Regulation of Dendritic Cell Function in Inflammation.Journal of immunology research · 2015Review
- A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells.Experimental eye research · 2014Article
- Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation.Mucosal immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world-wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.
objectiveIn this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.
methodsSera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose-blotted S. aureus, E. coli and gut bacterial antigens. IgE-reactive bacterial antigens were affinity purified and identified by mass spectrometry.
resultsMore than 30% of AD patients but not patients suffering only from allergic rhinoconjunctivitis and asthma or non-allergic persons exhibited IgE binding to several protein antigens among them DNA-binding and ribosomal proteins and flagellin. Patients with severe skin manifestations showed more frequently IgE reactivity to S. aureus compared with AD patients with mild symptoms. Positive immediate and late skin test reactions could be induced in sensitized AD patients with S. aureus extract. CONCLUSION AND CLINICAL RELEVANCE: Specific IgE reactivities against a variety of bacterial antigens were observed in a subgroup comprising a third of AD patients and may contribute to allergic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.