ArticleParasite immunology2011
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Article in Parasite immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026Review
- Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice.Nature microbiology · 2025Article
- Hematological and biochemical profiles, infection and habitat quality in an urban rat population.Scientific reports · 2025Article
- Enteric tuft cells coordinate timely expulsion of the tapeworm Hymenolepis diminuta from the murine host by coordinating local but not systemic immunity.PLoS pathogens · 2024Article
- Communication is key: Innate immune cells regulate host protection to helminths.Frontiers in immunology · 2022Review
- A lesson from the wild: The natural state of eosinophils is Ly6GImmunology · 2021Article
- Review
- Eosinophils and helminth infection: protective or pathogenic?Seminars in immunopathology · 2021Review
- Eosinophils Control Liver Damage by Modulating Immune Responses AgainstFrontiers in immunology · 2020Article
- Modulation of the immune response by helminths: a role for serotonin?Bioscience reports · 2018Review
- First Responders: Innate Immunity to Helminths.Trends in parasitology · 2018Review
- Immunity to gastrointestinal nematode infections.Mucosal immunology · 2018Review
- Type 2 cytokine responses: regulating immunity to helminth parasites and allergic inflammation.Current pharmacology reports · 2017Article
- Eosinophils in Helminth Infection: Defenders and Dupes.Trends in parasitology · 2016Review
- Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation.BMC immunology · 2016Article
- Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.PLoS pathogens · 2015Article
- Eosinophils mediate protective immunity against secondary nematode infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Heterogeneity across the murine small and large intestine.World journal of gastroenterology · 2014Review
- Eosinophil-derived IL-10 supports chronic nematode infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.Mucosal immunology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses. Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends critically on mounting of a Th2 response and represents a useful model system to investigate Th2 responses. Following infection of resistant BALB/c mice with T. muris, we observed accumulation of eosinophils in intestine-draining mesenteric lymph nodes (MLNs). The accumulation of MLN eosinophils was initiated during the second week of infection and peaked during worm expulsion. In contrast, we detected a comparably late and modest increase in eosinophil numbers in the MLNs of infected susceptible AKR mice. MLN eosinophils localized preferentially to the medullary region of the lymph node, displayed an activated phenotype and contributed to the interleukin-4 (IL-4) response in the MLN. Despite this, mice genetically deficient in eosinophils efficiently generated IL-4-expressing CD4(+) T cells, produced Th2 cytokines and mediated worm expulsion during primary T. muris infection. Thus, IL-4-expressing eosinophils accumulate in MLNs of T. muris-infected BALB/c mice but are dispensable for worm expulsion and generation of Th2 responses, suggesting a distinct or subtle role of MLN eosinophils in the immune response to T. muris infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.