ArticleThe Journal of experimental medicine1990
Preferential rearrangement of V kappa 4 gene segments in pre-B cell lines.
Article in The Journal of experimental medicine, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.Frontiers in immunology · 2023Article
- In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.Immunity · 2007Article
- Assembly and analysis of the mouse immunoglobulin kappa gene sequence.Immunogenetics · 2004Article
- Selection at multiple checkpoints focuses V(H)12 B cell differentiation toward a single B-1 cell specificity.The Journal of experimental medicine · 1999Article
- Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.The Journal of experimental medicine · 1995Article
- RAG-1 and RAG-2 are not sufficient to direct all phases of immunoglobulin gene rearrangement in pre-B-cell lines.Molecular and cellular biology · 1993Article
- Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.The Journal of experimental medicine · 1993Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.The Journal of experimental medicine · 1991Article
- Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes.Immunogenetics · 1991Article
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Authors and funding
2 authors.
Funding
Abstract
Examination of the in vitro V kappa gene rearrangements of murine adult bone marrow-derived pre-B cell lines reveals that 21 of 25 (84%) cell lines have rearranged a member of the V kappa 4 family. In contrast, analysis of two V kappa cDNA libraries prepared from LPS-stimulated adult spleen cells indicates that only 17% of the Ig kappa cDNAs contain sequences belonging to the V kappa 4 gene family. Half of the pre-B cell lines examined also share an 8-kbp BamHI reciprocal product (rp). However, these rp do not involve the same V kappa gene, indicating that conserved BamHI sites exist 3' of some V kappa genes. This rp is also readily detected in DNA from normal adult spleen cells, suggesting that the in vitro rearrangements examined in this study are representative of kappa rearrangements that occur in vivo. We suggest that, unlike the diverse V kappa repertoire expressed by mature B cells, the germline V kappa segments involved in initial rearrangements of the Ig kappa locus are highly restricted, and that an initial V kappa 4 rearrangement is probably followed by other, more random recombination events.
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