ArticleThe Journal of experimental medicine1990
Heavy-chain class switch does not terminate somatic mutation.
Article in The Journal of experimental medicine, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation.The Journal of experimental medicine · 2009Article
- Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.The Journal of clinical investigation · 2000Article
- Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Journal of immunology (Baltimore, Md. : 1950) · 1999Article
- The promotion of V region hypermutation.The Journal of experimental medicine · 1997Article
- The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.The Journal of experimental medicine · 1997Article
- Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.The EMBO journal · 1996Article
- Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.The Journal of experimental medicine · 1995Article
- Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.The Journal of clinical investigation · 1993Article
- Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.The Journal of experimental medicine · 1993Article
- DNA sequences at immunoglobulin switch region recombination sites.Nucleic acids research · 1993Review
- Natural occurrence and origin of somatically mutated memory B cells in mice.The Journal of experimental medicine · 1992Article
- Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.The Journal of clinical investigation · 1992Article
- B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.Immunology · 1992Article
- Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.The EMBO journal · 1991Article
- Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.The Journal of experimental medicine · 1991Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region-specific probes in Southern blot analysis individual mu-gamma switch rearrangement events can be distinguished. We show that clonally related IgG-producing hybridomas that differ by mutations often share a common switch rearrangement. This indicates that class switch in these cells did not terminate somatic mutation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.