SynthesisFuture microbiology2010
Serum Helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries.
Synthesis in Future microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Serum Helicobacter pylori CagA antibody may not be used as a tumor marker for diagnosing gastric cancer in east Asian countries.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Pooled it
- From infection to invasion: The role of deleted in malignant brain tumors 1 inWorld journal of clinical oncology · 2025Article
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- Vacuolating Cytotoxin A (VacA) and Extracellular Vesicles inIranian journal of pathology · 2025Review
- Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina.European journal of medical research · 2024Article
- A commentary on Helicobacter pylori and gastric cancer risk in BRCA1/2 pathogenic germline variant carrier.Journal of human genetics · 2023Article
- A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Article
- Overview ofGut and liver · 2021Review
- Helicobacter pylori in the Indonesian Malay's descendants might be imported from other ethnicities.Gut pathogens · 2021Article
- Type I and type IIWorld journal of gastroenterology · 2020Article
- Structure of cytotoxic associated antigen A protein ofVeterinary world · 2020Article
- Article
- Differences inJournal of clinical biochemistry and nutrition · 2019Article
- Epidemiology ofToxins · 2018Review
- Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males.Alimentary pharmacology & therapeutics · 2018Article
- Molecular mimicry inWorld journal of gastroenterology · 2017Review
- Novel CagA ELISA exhibits enhanced sensitivity ofWorld journal of gastroenterology · 2017Article
- Gut bacterial peptides with autoimmunity potential as environmental trigger for late onset complex diseases: In-silico study.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsIn east-Asian countries, while almost all Helicobacter pylori strains possess the cytotokine-associated gene A (CagA) gene, serum CagA antibody is not detected in some infected subjects. We aimed to clarify the association between anti-CagA antibody and gastric cancer in east-Asian countries. MATERIALS AND
methodsWe performed a meta-analysis of case-control studies with age- and sex-matched controls, which provided raw data in east-Asian countries.
resultsTen studies with a total of 4325 patients were identified in the search. Some reports from Japan, Korea and China showed a positive association between the presence of anti-CagA antibody and gastric cancer; however, the results differed in their various backgrounds. The disparate findings appeared to result from the use of different methods or from variations in the antigens used to detect the anti-CagA antibody. CagA seropositivity was associated with an increased risk of developing gastric cancer.
conclusionAnti-CagA antibody can be used as a biomarker for gastric cancer even in east-Asian countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.