ArticleWorld journal of gastroenterology2010
Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis.International journal of cancer · 2016Pooled it
- Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis.Epidemiology and infection · 2014Pooled it
- HPV-positive cancers at uncommon sites: a narrative review.Oncology reviews · 2026Review
- Review
- Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice?ESMO gastrointestinal oncology · 2024Review
- Review
- The complexity of human papilloma virus in cancers: a narrative review.Infectious agents and cancer · 2023Review
- Identification of hub pathways and drug candidates in gastric cancer through systems biology.Scientific reports · 2022Article
- p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection.Virchows Archiv : an international journal of pathology · 2021Article
- A Comprehensive Bioinformatic Analysis of NOTCH Pathway Involvement in Stomach Adenocarcinoma.Disease markers · 2021Article
- Association betweenWorld journal of gastroenterology · 2018Article
- HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana.TheScientificWorldJournal · 2018Article
- Frequency of Human Papillomavirus (HPV) 16 and 18 Detection in Paraffin- Embedded Laryngeal Carcinoma TissueAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Association of genotypes of rs671 withinCancer biology & medicine · 2017Article
- Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases.OncoTargets and therapy · 2016Article
- Microbiome, innate immunity, and esophageal adenocarcinoma.Clinics in laboratory medicine · 2014Review
- Potential role of human papilloma virus in the pathogenesis of gastric cancer.World journal of gastroenterology · 2014Article
- The absence of human papillomavirus in esophageal squamous cell carcinoma in East China.International journal of clinical and experimental pathology · 2014Article
- Human papillomavirus and the risk of Barrett's esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2013Article
- P16 and P53 Expression in Esophageal Squamous Cell Carcinoma: A Brief Report From The Experience of South of Iran, and Review of the Literature.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16(INK4A) protein expression.
methodsPolymerase chain reaction was used to detect the presence of HPV type16 (HPV16). The expression of P16(INK4A) protein was detected using immunohistochemistry.
resultsAmong the CC specimens, HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA), respectively (47% vs 29%), and two of both ESCC and GCA. P16(INK4A) was highly expressed in both ESCC and GCA. In the HPV-associated positive CC, higher P16(INK4A) expression was observed in the GCA than in the ESCC (75% vs 25%, P < 0.05).
conclusionHPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA. P16(INK4A) may be a screening index in the HPV-associated carcinoma of gastric cardia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.