ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2011
At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed.
- Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The antagonistic relationship between apoptosis and polyploidy in development and cancer.Seminars in cell & developmental biology · 2024Review
- Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells.Development (Cambridge, England) · 2024Article
- Polyploid Cancer Cell Models in Drosophila.Genes · 2024Review
- Finishing the egg.Genetics · 2024Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation.Development (Cambridge, England) · 2023Article
- Standardization of Single-Cell RNA-Sequencing Analysis Workflow to Study Drosophila Ovary.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Modeling Obesity-Associated Ovarian Dysfunction inNutrients · 2022Article
- Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells.Developmental biology · 2022Article
- Tumor models in various Drosophila tissues.WIREs mechanisms of disease · 2021Review
- Orphan nuclear receptor ftz-f1 (NR5A3) promotes egg chamber survival in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- Hedgehog Signaling: Implications in Cancers and Viral Infections.International journal of molecular sciences · 2021Review
- Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vector Rhodnius prolixus.Scientific reports · 2021Article
- Article
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- Downregulation of homeodomain protein Cut is essential forDevelopment (Cambridge, England) · 2019Article
- Tissue tension and not interphase cell shape determines cell division orientation in theThe EMBO journal · 2019Article
- Inhibition of Notch signaling by the p105 and p180 subunits ofJournal of cell science · 2019Article
- The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues.Advances in experimental medicine and biology · 2019Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Here, we discuss the findings to date about genes and pathways required for regulation of somatic follicle-cell proliferation and differentiation during Drosophila oogenesis and demonstrate how loss of these genes contributes to the tumorigenic potential of mutant cells. Follicle cells undergo cell-fate determination through stepwise activation of multiple signaling pathways, including the Notch, Hedgehog, Wingless, janus kinase/STAT, and JNK pathways. In addition, changes in DNA replication and cellular growth depend on the spatial and temporal activation of the mitotic cycle-endocycle and endocycle-gene amplification cell-cycle switches and insulin-dependent monitoring of cellular health; systemic loss of these pathways contributes to loss of controlled cellular proliferation, loss of differentiation/growth, and aberrant cell polarity in follicle cells. We also highlight the effects of the neoplastic and Hippo pathways on the cell cycle and cellular proliferation in promoting normal development and conclude that lack of coordination of multiple signaling pathways promotes conditions favorable for tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.