ReviewCurrent opinion in investigational drugs (London, England : 2000)2010
Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?
Review in Current opinion in investigational drugs (London, England : 2000), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Trial
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- A Pilot Study: Contrasting Genomic Profiles of Lung Adenocarcinoma Between Patients of European and Latin American Ancestry.International journal of molecular sciences · 2025Article
- Metabolomics analysis of human cumulus cells obtained from cumulus-oocyte complexes with different developmental potential.Human reproduction (Oxford, England) · 2023Article
- L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.Nutrients · 2022Article
- Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer.International journal of molecular sciences · 2020Review
- Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How.International journal of molecular sciences · 2020Review
- Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease.Frontiers in neuroscience · 2020Review
- Amino acids and amino acid sensing: implication for aging and diseases.Biogerontology · 2019Review
- mTORC1 as the main gateway to autophagy.Essays in biochemistry · 2017Review
- The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies.Current topics in developmental biology · 2017Review
- Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells.PLoS genetics · 2016Article
- Article
- Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot.Cell metabolism · 2016Review
- Article
- A human leucyl-tRNA synthetase as an anticancer target.OncoTargets and therapy · 2015Article
- BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior.The Journal of cell biology · 2014Article
- Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated.Amino acids · 2013Article
- Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis.Oncogene · 2013Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a multicomponent, nutrient-sensitive protein that is implicated in a wide range of major human diseases. mTORC1 responds to both growth factors and changes in local amino acid levels. Until recently, the intracellular amino acid-sensing mechanism that regulates mTORC1 had remained unexplored. However, studies in human cells in culture have demonstrated that in response to amino acid stimulation, mTOR (a conserved member of the PI3K superfamily) is shuttled to late endosomal and lysosomal compartments, where it binds the Ragulator-Rag complex and is assembled into active mTORC1. Members of the proton-assisted amino acid transporter (PAT/SLC36) family have been identified as critical components of the amino acid-sensing system that regulates mTORC1 present in endosomal and lysosomal membranes. These discoveries not only highlight several new potential drug targets that could impact selectively on mTORC1 activity in cancer cells, but also provide novel insights into the strategies used by such cells to outcompete their neighbors in growth factor- and nutrient-depleted conditions. In this review, recent mechanistic insights into how mTORC1 activity is controlled by amino acids and the potential for the selective targeting this regulatory input are discussed.
Indexed as
Identifiers
21154118PMC3044466W78262552What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.