ArticleBehavior genetics2011
Mapping Loci for fox domestication: deconstruction/reconstruction of a behavioral phenotype.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Gut microbiome community structure correlates with different behavioral phenotypes in the Belyaev Farm-Fox Experiment.Communications biology · 2026Article
- Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness.Genes, brain, and behavior · 2024Article
- The brain of the silver fox (Vulpes vulpes): a neuroanatomical reference of cell-stained histological and MRI images.Brain structure & function · 2023Article
- Defining hippocampal area CA2 in the fox (Vulpes vulpes) brain.Hippocampus · 2023Article
- Linking vgll3 genotype and aggressive behaviour in juvenile Atlantic salmon (Salmo salar).Journal of fish biology · 2022Article
- Article
- Comparative transcriptome provides insights into the selection adaptation between wild and farmed foxes.Ecology and evolution · 2021Article
- Article
- Spatial Aspects of Gardens Drive Ranging in Urban Foxes (Animals : an open access journal from MDPI · 2020Article
- Heritability of interpack aggression in a wild pedigreed population of North American grey wolves.Molecular ecology · 2020Article
- Deciphering the puzzles of dog domestication.Zoological research · 2020Review
- Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals.BMC genomics · 2020Article
- Genomic responses to selection for tame/aggressive behaviors in the silver fox (Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.Nature ecology & evolution · 2018Article
- Article
- Nature versus nurture? Consequences of short captivity in early stages.Ecology and evolution · 2018Article
- Selective breeding and selection mapping using a novel wild-derived heterogeneous stock of mice revealed two closely-linked loci for tameness.Scientific reports · 2017Article
- Domestication and tameness: brain gene expression in red junglefowl selected for less fear of humans suggests effects on reproduction and immunology.Royal Society open science · 2016Article
- Georgian white coat color of red fox (Vulpes vulpes) maps to fox chromosome 2 in the region containing KIT gene.Animal genetics · 2016Article
- Genetic mapping of natural variation in schooling tendency in the threespine stickleback.G3 (Bethesda, Md.) · 2015Article
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Authors and funding
14 authors.
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Abstract
During the second part of the twentieth century, Belyaev selected tame and aggressive foxes (Vulpes vulpes), in an effort known as the "farm-fox experiment", to recapitulate the process of animal domestication. Using these tame and aggressive foxes as founders of segregant backcross and intercross populations we have employed interval mapping to identify a locus for tame behavior on fox chromosome VVU12. This locus is orthologous to, and therefore validates, a genomic region recently implicated in canine domestication. The tame versus aggressive behavioral phenotype was characterized as the first principal component (PC) of a PC matrix made up of many distinct behavioral traits (e.g. wags tail; comes to the front of the cage; allows head to be touched; holds observer's hand with its mouth; etc.). Mean values of this PC for F1, backcross and intercross populations defined a linear gradient of heritable behavior ranging from tame to aggressive. The second PC did not follow such a gradient, but also mapped to VVU12, and distinguished between active and passive behaviors. These data suggest that (1) there are at least two VVU12 loci associated with behavior; (2) expression of these loci is dependent on interactions with other parts of the genome (the genome context) and therefore varies from one crossbred population to another depending on the individual parents that participated in the cross.
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