ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Immediate early inflammatory gene responses of human umbilical vein endothelial cells to hemorrhagic venom.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Intracellular Zinc Trafficking duringInternational journal of molecular sciences · 2023Article
- Article
- EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells.International journal of inflammation · 2015Article
- Characterization of crude Echis carinatus venom-induced cytotoxicity in HEK 293T cells.Journal of venom research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designThis report describes a focused immediate early gene response by human umbilical vein endothelial cells (HUVEC) to Echis carinatus snake venom. MATERIALS OR SUBJECTS: Primary cultures of HUVEC were used to assess acute inflammatory gene responses. TREATMENTS: Crude E. carinatus venom (2.5 µg/ml) was used to stimulate HUVEC.
resultsHUVEC stimulated for 3 h with E. carinatus venom showed a focused response to the venom, with significant increases in metallothionein (e.g., MT1H, MT2A, MT1X) and cytochrome P450 (e.g., CYP1A1, CYP1B1) gene expressions compared to non-stimulated controls. Several other genes involved in cell growth and matrix attachment were repressed [e.g., thrombospondin 1 (THBS1), connective tissue growth factor (CTGF)].
conclusionsThese data suggest that acute vascular injury induced by hemorrhagic snake venom initiates an anti-oxidant response primarily involving metallothioneins.
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Registered trials
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