ArticleParasitology research2011
Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis.
Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Diversity of Ethiopian Black Cumin (Biochemistry research international · 2025Article
- Recent Updates on Interaction Studies and Drug Delivery of Antimalarials with Serum Albumin Proteins.Current medicinal chemistry · 2024Review
- Use of nanoparticles, a modern means of drug delivery, against cryptosporidiosis.Journal of advanced veterinary and animal research · 2023Review
- Black Seed (Nigella sativa): A Favourable Alternative Therapy for Inflammatory and Immune System Disorders.Inflammopharmacology · 2022Review
- A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (Foods (Basel, Switzerland) · 2022Review
- Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities.BMC complementary medicine and therapies · 2022Article
- Recent Progress on Chemical Constituents and Pharmacological Effects of the GenusEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Effects of Eugenol onBioscience reports · 2019Article
- Review
- A Review on the Cosmeceutical and External Applications ofJournal of tropical medicine · 2017Review
- Effect of Nigella sativa oil on experimental toxoplasmosis.Parasitology research · 2016Article
- Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice.African health sciences · 2015Article
- Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects.Iranian journal of basic medical sciences · 2014Review
- In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces.Iranian journal of basic medical sciences · 2014Article
- Scolicidal effects of black cumin seed (Nigella sativa) essential oil on hydatid cysts.The Korean journal of parasitology · 2014Article
- Dietary supplementation of chloroquine with nigella sativa seed and oil extracts in the treatment of malaria induced in mice with plasmodium berghei.Pharmacognosy magazine · 2014Article
- In vivo antimalarial activity of Trichilia megalantha harms extracts and fractions in animal models.Parasitology research · 2013Article
- Protective effect of quercetin on chloroquine-induced oxidative stress and hepatotoxicity in mice.Malaria research and treatment · 2013Article
- Oxidative stress in malaria.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (MENS) were investigated against established malaria infection in vivo using Swiss albino mice. The antimalarial activity of the extract against Plasmodium yoelli nigeriensis (P. yoelli) was assessed using the Rane test procedure. Chloroquine (CQ)-treated group served as positive control. The extract, at a dose of 1.25 g/kg body weight significantly (p<0.05) suppressed P. yoelli infection in the mice by 94%, while CQ, the reference drug, produced 86% suppression when compared to the untreated group after the fifth day of treatment. P. yoelli infection caused a significant (p<0.05) increase in the levels of red cell and hepatic malondialdehyde (MDA), an index of lipid peroxidation (LPO) in the mice. Serum and hepatic LPO levels were increased by 71% and 113%, respectively, in the untreated infected mice. Furthermore, P. yoelli infection caused a significant (p<0.05) decrease in the activities of superoxide dismutase, catalase, glutathione-S-transferase and the level of reduced glutathione in tissues of the mice. Treatment with MENS significantly (p<0.05) attenuated the serum and hepatic MDA levels in P. yoelli-infected mice. In addition, MENS restored the activities of red cell antioxidant enzymes in the infected mice to near normal. Moreover, MENS was found to be more effective than CQ in parasite clearance and, in the restoration of altered biochemical indices by P. yoelli infection. These results suggest that N. sativa seeds have strong antioxidant property and, may be a good phytotherapeutic agent against Plasmodium infection in malaria.
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