Trial reportPsychopharmacology2011
Modafinil modulation of the default mode network.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Neural bases of pharmacological treatment of nicotine dependence - insights from functional brain imaging: a systematic review.CNS drugs · 2013Pooled it
- Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.Psychopharmacology · 2019Trial
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- Methylene blue modulates functional connectivity in the human brain.Brain imaging and behavior · 2017Trial
- Examining the efficacy of d-cycloserine to augment therapeutic learning in depression.Contemporary clinical trials · 2016Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens.Psychopharmacology · 2014Trial
- Acute effects of modafinil on brain resting state networks in young healthy subjects.PloS one · 2013Trial
- Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.PloS one · 2013Trial
- Deep brain stimulation of the subthalamic nucleus, but not dopaminergic medication, improves proactive inhibitory control of movement initiation in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Trial
- NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2012Trial
- Modafinil, an atypical CNS stimulant?Advances in pharmacology (San Diego, Calif.) · 2024Article
- Effects of modafinil on electroencephalographic microstates in healthy adults.Psychopharmacology · 2022Article
- Multimodal brain deficits shared in early-onset and adult-onset schizophrenia predict positive symptoms regardless of illness stage.Human brain mapping · 2022Article
- Neurometabolic and functional changes of default-mode network relate to clinical recovery in first-episode psychosis patients: A longitudinalNeuroImage. Clinical · 2022Article
- The Bilateral Precuneus as a Potential Neuroimaging Biomarker for Right Temporal Lobe Epilepsy: A Support Vector Machine Analysis.Frontiers in psychiatry · 2022Article
- A Dissociation in Effects of Risperidone Monotherapy on Functional and Anatomical Connectivity Within the Default Mode Network.Schizophrenia bulletin · 2019Article
- Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms.Neuroscience bulletin · 2019Article
- Developmental Changes in Task-Induced Brain Deactivation in Humans Revealed by a Motor Task.Developmental neurobiology · 2019Article
- Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network.Human brain mapping · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleThe default mode network (DMN) is a functional network which is implicated in a range of cognitive processes. This network is proposed to consist of hubs located in the ventromedial prefrontal cortex (vmPFC), posterior cingulate/retrosplenial cortex (PCC/rSpl), and inferior parietal lobule (IPL), with other midline cortical and temporal lobe nodes connected to these hubs. How this network is modulated by neurochemical systems during functional brain activity is not yet understood.
objectivesIn the present study, we used the norepinephrine/dopamine transporter inhibitor modafinil to test the hypothesis that this drug modulates the DMN.
methodsEighteen healthy right-handed adults participated in a double-blind, placebo-controlled study of single oral dose modafinil 200 mg. They performed a simple visual sensorimotor task during slow event-related fMRI. Drug effects were interrogated within the DMN defined by task-induced deactivation (TID) on placebo.
resultsThere was a trend toward faster reaction time (RT) on modafinil (Cohen's d = 0.38). Brain regions within the DMN which exhibited significant modafinil-induced augmentation of TID included vmPFC, PCC/rSpl, and left IPL. Across subjects, the modafinil effect on TID in the vmPFC was significantly and specifically associated with drug effects on RT speeding.
conclusionsModafinil augments TID in the DMN to facilitate sensorimotor processing speed, an effect which may be particularly dependent on changes in vmPFC activity. This is consistent with the gain control function of catecholamine systems and may represent an important aspect of the pro-cognitive effects of modafinil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.