ArticleThe Journal of membrane biology2011
TEA-sensitive currents contribute to membrane potential of organ surface primo-node cells in rats.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Identification of Primo-Vascular System in Abdominal Subcutaneous Tissue Layer of Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- The primo vascular structures alongside nervous system: its discovery and functional limitation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- The characteristics of action potentials in primo vessels and the effects of acetylcholine injection to the action potentials.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- History of bioelectrical study and the electrophysiology of the primo vascular system.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Gross morphological features of the organ surface primo-vascular system revealed by hemacolor staining.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Mathematical Distinction in Action Potential between Primo-Vessels and Smooth Muscle.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Patch clamp: a powerful technique for studying the mechanism of acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primo-vascular (Bonghan) tissue has been identified in most tissues in the body, but its structure and functions are not yet well understood. We characterized electrophysiological properties of the cells of the primo-nodes (PN) on the surface of abdominal organs using a slice patch clamp technique. The most abundant were small round cells (~10 μm) without processes. These PN cells exhibited low resting membrane potential (-36 mV) and did not fire action potentials. On the basis of the current-voltage (I-V) relationships and kinetics of outward currents, the PN cells can be grouped into four types. Among these, type I cells were the majority (69%); they showed strong outward rectification in I-V relations. The outward current was activated rapidly and sustained without decay. Tetraethylammonium (TEA) dose-dependently blocked both outward and inward current (IC(50), 4.3 mM at ± 60 mV). In current clamp conditions, TEA dose-dependently depolarized the membrane potential (18.5 mV at 30 mM) with increase in input resistance. The tail current following a depolarizing voltage step was reversed at -27 mV, and transient outward current like A-type K(+) current was not expressed at holding potential of -80 mV. Taken together, the results demonstrate for the first time that the small round PN cells are heterogenous, and that, in type I cells, TEA-sensitive current with limited selectivity to K(+) contributed to resting membrane potential of these cells.
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