ArticleIntensive care medicine2011
Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
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- Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial.Critical care (London, England) · 2011Trial
- Exploratory clinical trial on the acoustic variability index for predicting fluid responsiveness during hepatectomy.Journal of clinical monitoring and computing · 2026Observational
- Trendelenburg maneuver to predict fluid responsiveness in patients under mechanical ventilation with spontaneous breathing: a prospective study.BMC anesthesiology · 2026Article
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- Detection of fluid responsiveness by changes of perfusion index and pleth-variability index during passive leg raising in spontaneously breathing post-surgical patients: a prospective interventional study.Journal of clinical monitoring and computing · 2025Article
- Monitoring cardiac output.Intensive care medicine · 2024Article
- Internal jugular vein collapsibility does not predict fluid responsiveness in spontaneously breathing patients after cardiac surgery.Journal of clinical monitoring and computing · 2023Observational
- Prediction of Fluid Responsiveness Using Combined End-Expiratory and End-Inspiratory Occlusion Tests in Cardiac Surgical Patients.Journal of clinical medicine · 2023Article
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- Safety during interhospital helicopter transfer of ventilated COVID-19 patients. No clinical relevant changes in vital signs including non-invasive cardiac output.Respiratory research · 2022Article
- Optimal Perfusion Targets in Cardiogenic Shock.JACC. Advances · 2022Review
- Bioreactance and fourth-generation pulse contour methods in monitoring cardiac index during off-pump coronary artery bypass surgery.Journal of clinical monitoring and computing · 2022Article
- Colorectal Surgery in Critically Unwell Patients: A Multidisciplinary Approach.Clinics in colon and rectal surgery · 2022Review
- Correlation of Cardiac Output by Arterial Contour-Derived Cardiac Output Monitor Versus Pulmonary Artery Catheter in Liver Transplant: Experience at an Indian Center.Turkish journal of anaesthesiology and reanimation · 2022Article
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSecond-generation FloTrac software has been shown to reliably measure cardiac output (CO) in cardiac surgical patients. However, concerns have been raised regarding its accuracy in vasoplegic states. The aim of the present multicenter study was to investigate the accuracy of the third-generation software in patients with sepsis, particularly when total systemic vascular resistance (TSVR) is low.
methodsFifty-eight septic patients were included in this prospective observational study in four university-affiliated ICUs. Reference CO was measured by bolus pulmonary thermodilution (iCO) using 3-5 cold saline boluses. Simultaneously, CO was computed from the arterial pressure curve recorded on a computer using the second-generation (CO(G2)) and third-generation (CO(G3)) FloTrac software. CO was also measured by semi-continuous pulmonary thermodilution (CCO).
resultsA total of 401 simultaneous measurements of iCO, CO(G2), CO(G3), and CCO were recorded. The mean (95%CI) biases between CO(G2) and iCO, CO(G3) and iCO, and CCO and iCO were -10 (-15 to -5)% [-0.8 (-1.1 to -0.4) L/min], 0 (-4 to 4)% [0 (-0.3 to 0.3) L/min], and 9 (6-13)% [0.7 (0.5-1.0) L/min], respectively. The percentage errors were 29 (20-37)% for CO(G2), 30 (24-37)% for CO(G3), and 28 (22-34)% for CCO. The difference between iCO and CO(G2) was significantly correlated with TSVR (r(2) = 0.37, p < 0.0001). A very weak (r(2) = 0.05) relationship was also observed for the difference between iCO and CO(G3).
conclusionsIn patients with sepsis, the third-generation FloTrac software is more accurate, as precise, and less influenced by TSVR than the second-generation software.
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