ArticleEndocrine1996
Characterization of the second messengers involved in 1α,25-dihydroxyvitamin D(3) stimulated intestinal calcium absorption (transcaltachia).
Article in Endocrine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
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Abstract
1α,25-Dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)] has been shown to generate biological responses via both genomic and nongenomic pathways. In the nongenomic process, 1α,25(OH)(2)D(3) stimulates the rapid transport of Ca(2+) across the chick intestinal epithelial cell, a process termed transcaltachia. In previous studies, the involvement of Ca(2+)-channels, protein kinase C, and cAMP-dependent kinase in the 1α,25(OH)(2)D(3) stimulated transcaltachic response have been implicated. To further characterize the elements involved in mediating the transcaltachic effect, H7, an inhibitor of protein kinase C, U73122, an inhibitor of phospholipase C, and mastoparan, an activator of G-proteins, were employed. Both H7 and U73122 suppressed 1α,25(OH)(2)D(3) stimulated intestinal Ca(2+) transport. Mastoparan was found to mimic the effect of 1α,25(OH)(2)D(3) to stimulate transcaltachia. Collectively, these results suggest that 1α,25(OH)(2)D(3) activations of G-proteins, phospholipase C and protein kinases are essential steps in the rapid stimulation of intestinal Ca(2+) transport.
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