SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2011
Intestinal cancer risk in Crohn's disease: a meta-analysis.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Inflammatory bowel disease (IBD) position statement of the Italian Society of Colorectal Surgery (SICCR): general principles of IBD management.Techniques in coloproctology · 2020Guideline
- ACG Clinical Guideline: Management of Crohn's Disease in Adults.The American journal of gastroenterology · 2018Guideline
- The histopathological approach to inflammatory bowel disease: a practice guide.Virchows Archiv : an international journal of pathology · 2014Guideline
- Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.International journal of cancer · 2015Trial
- Malignancy in Long-Standing Perianal Fistulizing Crohn's Disease: Too Little, Too Late.Digestive diseases and sciences · 2026Article
- High-Grade Small Bowel Dysplasia Following Prior Adenocarcinoma in Small Bowel Crohn's Disease.Cureus · 2026Article
- Review
- A Guide Through the Tunnel: Updates in the Approach to Classification and Management of Perianal Fistulizing Crohn's Disease.Current gastroenterology reports · 2025Review
- Article
- Review
- Ultrasound of the bowel with a focus on IBD: the new best practice.Abdominal radiology (New York) · 2025Review
- Clinical Characteristics and Outcomes of Small Bowel Neoplasms in Crohn's Disease: A Case-Control Study.Crohn's & colitis 360 · 2025Article
- Pediatric inflammatory bowel disease and cancer.Frontiers in immunology · 2025Review
- Gastrointestinal endoscopy for intestinal dysplasia and neoplasia detection and management in Crohn's disease: when and how?Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Review
- The Descriptive and Disproportionality Assessment of EudraVigilance Database Reports on Capecitabine Induced Cardiotoxicity.Cancers · 2024Article
- Perianal Crohn's disease: Still more questions than answers.World journal of gastroenterology · 2024Article
- Small Bowel Cancer in Crohn's Disease.Cancers · 2024Review
- Possible poor prognosis in younger-onset Crohn's disease-associated anorectal cancer: A subanalysis of the Nationwide Japanese study.Annals of gastroenterological surgery · 2024Article
- Incidence of intestinal & extra-intestinal cancers among individuals with Crohn's disease in northern India.The Indian journal of medical research · 2024Article
- Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023.Intestinal research · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studyTo clarify the intestinal cancer risk in Crohn's disease (CD).
methods20 clinical studies (1965-2008) with a total of 40,547 patients with Crohn's disease-associated cancer (CDAC) were included in the meta-analysis ("inverse variance weighted" method).
resultsThe incidence of CDAC in any CD patient was 0.8/1,000 person years duration (pyd) (CI, 0.6-1.0). The incidences of different carcinomas were: colorectal cancer 0.5/1,000 pyd (CI, 0.3-0.6), small bowel carcinoma 0.3/1,000 pyd (CI, 0.1-0.5), and cancers arising from CD-associated fistulae 0.2/1,000 pyd (CI, 0.0-0.4). Compared to the incidence in an age-matched standard population, the risk of colorectal cancer was increased by factor 2-3 and of small bowel cancer by factor 18.75, respectively. Mean patient age at diagnosis of CD-associated colorectal cancer was 51.5 years, thus 20 years earlier than in a standard population. The mean duration of CD until diagnosis of CDAC was 18.3 years. Duration of CD, age at diagnosis of CD, and anatomical area of CD involvement had no significant influence on cancer incidence.
conclusionsCD is a risk factor for colorectal cancer, small bowel cancer, and fistula cancer; however, compared to ulcerative colitis, cancer risk is moderate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.