ArticleMolecular biology reports2011
Biological role of microRNA-103 based on expression profile and target genes analysis in pigs.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
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- Regulation of mRNA and miRNA in the response to Salmonella enterica serovar Enteritidis infection in chicken cecum.BMC veterinary research · 2022Article
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- ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targetingInternational journal of biological sciences · 2017Article
- miR-146a-5p inhibits TNF-α-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes.Journal of lipid research · 2016Article
- Validation study of candidate single nucleotide polymorphisms associated with left ventricular hypertrophy in the Korean population.BMC medical genetics · 2015Article
- microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells.Stem cells and development · 2015Review
- MicroRNA-33b downregulates the differentiation and development of porcine preadipocytes.Molecular biology reports · 2014Article
- Integrated analysis of miRNA and mRNA during differentiation of human CD34+ cells delineates the regulatory roles of microRNA in hematopoiesis.Experimental hematology · 2014Article
- Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties.BMC genomics · 2013Article
- MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing.PloS one · 2013Article
- RAI14 Regulated by circNFATC3/miR-23b-3p axis Facilitates Cell Growth and Invasion in Gastric Cancer.Cell transplantationArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are endogenously expressed RNAs consisting of 20-24 nucleotides. These molecules are thought to repress protein translation by binding to target mRNAs. However, biological functions have not been assigned to most of the 175 porcine miRNAs registered in miRBase (release 15.0). In an effort to uncover miR-103 important in pigs, we examined the integrative tissue expression profile and gene ontology (GO) term enrichment of predicted target genes to determine the global biological functions of miR-103. Our results demonstrated that miR-103 is involved in various biological processes including brain development, lipid metabolism, adipocyte differentiation, hematopoiesis, and immunity. Moreover, we also experimentally verified effects of miR-103 in porcine preadipocytes. miR-103 levels increased in differentiating adipocytes, and inhibition of miR-103 effectively inhibited preadipocyte differentiation. In addition, mRNA levels of the putative miR-103 target RAI14 were higher in miR-103 inhibitor-treated adipocytes. These results demonstrate that miR-103 is involved in porcine preadipocyte differentiation and may act through the putative target gene RAI14. In a word, our data provide new insights into the global biological role of miR-103.
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