ArticleAnnals of biomedical engineering2011
Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways.
Article in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of the predictive capability of modelling and simulation to determine bioequivalence of inhaled drugs: A systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Pooled it
- Direct Numerical Simulations of Inhalation in a 23-Generation Lung Model.International journal for numerical methods in biomedical engineering · 2026Article
- CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review.Pharmaceutical research · 2026Review
- How Breathing Interruptions Influence pMDI Aerosol Delivery: A CFD Study in a Realistic Airway.Pharmaceutical research · 2026Article
- Pulmonary Function Prediction Method Based on Convolutional Surface Modeling and Computational Fluid Dynamics Simulation.Healthcare (Basel, Switzerland) · 2025Article
- Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels.Journal of aerosol science · 2024Article
- Independent Lung Ventilation-Experimental Studies on a 3D Printed Respiratory Tract Model.Materials (Basel, Switzerland) · 2021Article
- High-Efficiency Dry Powder Aerosol Delivery to Children: Review and Application of New Technologies.Journal of aerosol science · 2021Article
- SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry.Physics of fluids (Woodbury, N.Y. : 1994) · 2021Article
- Combined in Vitro-in Silico Approach to Predict Deposition and Pharmacokinetics of Budesonide Dry Powder Inhalers.Pharmaceutical research · 2020Article
- Radiation Dosimetry of Inhaled Radioactive Aerosols: CFPD and MCNP Transport Simulations of Radionuclides in the Lung.Scientific reports · 2019Article
- Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2019Review
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- Aerosol Drug Delivery During Noninvasive Positive Pressure Ventilation: Effects of Intersubject Variability and Excipient Enhanced Growth.Journal of aerosol medicine and pulmonary drug delivery · 2017Article
- In vitro dose comparison of RespimatInternational journal of chronic obstructive pulmonary disease · 2017Article
- Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs.Journal of pharmaceutical sciences · 2016Article
- Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data.Pharmaceutical research · 2015Article
- Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler.Journal of aerosol medicine and pulmonary drug delivery · 2015Article
- Variability in Nose-to-Lung Aerosol Delivery.Journal of aerosol science · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The objective of this study was to evaluate the delivery of inhaled pharmaceutical aerosols using an enhanced condensational growth (ECG) approach in an airway model extending from the oral cavity to the end of the tracheobronchial (TB) region. The geometry consisted of an elliptical mouth-throat (MT) model, the upper TB airways extending to bifurcation B3, and a subsequent individual path model entering the right lower lobe of the lung. Submicrometer monodisperse aerosols with diameters of 560 and 900 nm were delivered to the mouth inlet under control (25 °C with subsaturated air) or ECG (39 or 42 °C with saturated air) conditions. Flow fields and droplet characteristics were simulated using a computational fluid dynamics model that was previously demonstrated to accurately predict aerosol size growth and deposition. Results indicated that both the control and ECG delivery cases produced very little deposition in the MT and upper TB model (approximately 1%). Under ECG delivery conditions, large size increases of the aerosol droplets were observed resulting in mass median aerodynamic diameters of 2.4-3.3 μm exiting B5. This increase in aerosol size produced an order of magnitude increase in aerosol deposition within the TB airways compared with the controls, with TB deposition efficiencies of approximately 32-46% for ECG conditions. Estimates of downstream pulmonary deposition indicted near full lung retention of the aerosol during ECG delivery. Furthermore, targeting the region of TB deposition by controlling the inlet temperature conditions and initial aerosol size also appeared possible.
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