ArticleMarine biotechnology (New York, N.Y.)2011
Gram-positive marine bacteria as a potential resource for the discovery of quorum sensing inhibitors.
Article in Marine biotechnology (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- Quorum Sensing Inhibition by Sponge-AssociatedAntibiotics (Basel, Switzerland) · 2025Article
- Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- Diversity of Bacteria with Quorum Sensing and Quenching Activities from Hydrothermal Vents in the Okinawa Trough.Microorganisms · 2023Article
- Review
- Screening strategies for quorum sensing inhibitors in combating bacterial infections.Journal of pharmaceutical analysis · 2022Review
- Article
- A Cyclic Dipeptide from Marine FungusACS omega · 2021Article
- Marine bacteria associated with shallow hydrothermal systems in the Gulf of California with the capacity to produce biofilm inhibiting compounds.Archives of microbiology · 2020Article
- ExtremophilicFrontiers in microbiology · 2020Article
- Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria.Microbial biotechnology · 2019Article
- A Quorum-Sensing Inhibitor Strain ofMarine drugs · 2019Article
- Quorum Sensing Inhibition by Marine Bacteria.Marine drugs · 2019Review
- Antagonism of Quorum Sensing Phenotypes by Analogs of the Marine Bacterial Secondary Metabolite 3-Methyl-Marine drugs · 2019Article
- Widespread Existence of Quorum Sensing Inhibitors in Marine Bacteria: Potential Drugs to Combat Pathogens with Novel Strategies.Marine drugs · 2019Review
- Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review.Marine drugs · 2019Review
- Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives.Marine drugs · 2019Review
- The Probiotic Bacterium Phaeobacter inhibens Downregulates Virulence Factor Transcription in the Shellfish Pathogen Vibrio coralliilyticus byApplied and environmental microbiology · 2019Article
- Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression.Journal, genetic engineering & biotechnology · 2018Review
- Anti-quorum Sensing Activities of Selected Coral Symbiotic Bacterial Extracts From the South China Sea.Frontiers in cellular and infection microbiology · 2018Article
- Strain identification and quorum sensing inhibition characterization of marine-derivedRoyal Society open science · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitors of bacterial quorum sensing have been proposed as potentially novel therapeutics for the treatment of certain bacterial diseases. We recently reported a marine Halobacillus salinus isolate that secretes secondary metabolites capable of quenching quorum sensing phenotypes in several Gram-negative reporter strains. To investigate how widespread the production of such compounds may be in the marine bacterial environment, 332 Gram-positive isolates from diverse habitats were tested for their ability to interfere with Vibrio harveyi bioluminescence, a cell signaling-regulated phenotype. Rapid assay methods were employed where environmental isolates were propagated alongside the reporter strain. "Actives" were defined as bacteria that interfered with bioluminescence without visible cell-killing effects (antibiotic activity). A total of 49 bacterial isolates interfered with bioluminescence production in the assays. Metabolite extracts were generated from cultures of the active isolates, and 28 reproduced the bioluminescence inhibition against V. harveyi. Of those 28, five extracts additionally inhibited violacein production by Chromobacterium violaceum. Chemical investigations revealed that phenethylamides and a cyclic dipeptide are two types of secondary metabolites responsible for the observed activities. The active bacterial isolates belonged primarily to either the genus Bacillus or Halobacillus. The results suggest that Gram-positive marine bacteria are worthy of further investigation for the discovery of quorum sensing antagonists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.